Journal ArticleDOI
Morphofunctional mitochondrial response to methylglyoxal toxicity in Bufo bufo embryos.
Fernanda Amicarelli,Sabrina Colafarina,Patrizia Cesare,Pierpaolo Aimola,C Di Ilio,Michele Miranda,Anna Maria Ragnelli +6 more
TLDR
The morphofunctional effect of methylglyoxal on the common toad B. bufo embryo mitochondria is investigated to verify if its dysmorphogenetic action might be also ascribed to impairment of mitochondrial functions.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2001-11-01. It has received 22 citations till now. The article focuses on the topics: Methylglyoxal & Mitochondrion.read more
Citations
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Journal ArticleDOI
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
TL;DR: The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden.
Journal ArticleDOI
Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes.
Paul J. Beisswenger,Scott K. Howell,Scott K. Howell,Kenneth Smith,Kenneth Smith,Benjamin S. Szwergold,Benjamin S. Szwergold +6 more
TL;DR: It is postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for the wide varying rates of progression of diabetic complications seen among individuals.
Journal ArticleDOI
Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury
Fernanda Amicarelli,Sabrina Colafarina,Franca Cattani,Annamaria Cimini,Carmine Di Ilio,Maria Paola Cerù,Michele Miranda +6 more
TL;DR: Evaluated the signaling transduction pathway elicited by methylglyoxal in human glioblastoma (ADF) and neuroblastoma (SH-SY 5Y) cells and shows that methyl glyoxal causes early and extensive reactive oxygen species generation in both cell lines, emphasizing the pivotal role of antioxidant and detoxifying systems in determining the grade of sensitivity of cells to methylgly oxal.
Journal ArticleDOI
Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1β and nerve growth factor in cultured hippocampal neuronal cells
Silvia Di Loreto,Valentina Caracciolo,Sabrina Colafarina,Pierluigi Sebastiani,Antonella Gasbarri,Fernanda Amicarelli +5 more
TL;DR: Results show that hippocampal neurons are strongly susceptible to MG-mediated oxidative stress, and co-treatment with the antioxidant N-acetylcysteine (NAC) completely abrogates the observed effects.
Journal ArticleDOI
The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III.
Alejandro Gugliucci,T. Menini +1 more
TL;DR: A system of whole plasma glycation over 16 h with micromolar concentrations of MG, coupled with the measurement of activities of plasminogen and AT III by specific substrates provides a straightforward, practical method for monitoring the action of putative antiglycation agents.
References
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Book
Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
Journal ArticleDOI
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
TL;DR: The results indicate that BID is a mediator of mitochondrial damage induced by Casp8, and coexpression of BclxL inhibits all the apoptotic changes induced by tBID.
Journal ArticleDOI
BCL-2 family members and the mitochondria in apoptosis
TL;DR: As the BCL-2 family members reside upstream of irreversible cellular damage and focus much of their efforts at the level of mitochondria, they play a pivotal role in deciding whether a cell will live or die, and it is argued that the amphipathic a-helical BH3 domain serves as a critical death domain in the pro-apoptotic members.
Book ChapterDOI
d-Glucose: Determination with Hexokinase and Glucose-6-phosphate Dehydrogenase
TL;DR: This chapter discusses an enzymatic method for the determination of D -glucose with hexokinase and glucose-6-phosphate dehydrogenase, a method based on the optical method developed by O. Warburg and his collaborators.
Journal ArticleDOI
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
TL;DR: Investigation has brought new developments in the involvement of the glyoxalase in cell growth and vesicle mobilization, with increasing evidence of changes in the gly oxalase system during tumor growth and diabete mellitus, particularly relating to the development of associated clinical complications.