Journal ArticleDOI
MRI-based finite-element analysis of left ventricular aneurysm
Joseph C. Walker,Mark B. Ratcliffe,Peng Zhang,Arthur W. Wallace,Bahar Fata,Edward W. Hsu,David Saloner,Julius M. Guccione +7 more
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TLDR
Systolic material parameters were determined that enabled FE models to reproduce midwall, systolic myocardial strains from tagged MRI, and contrary to previous hypotheses but consistent with biaxial stretching experiments, active cross-fiber stress development is an integral part of LV systole.Abstract:
Tagged MRI and finite-element (FE) analysis are valuable tools in analyzing cardiac mechanics. To determine systolic material parameters in three-dimensional stress-strain relationships, we used ta...read more
Citations
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Journal ArticleDOI
Theoretical impact of the injection of material into the myocardium: a finite element model simulation.
TL;DR: Simulations indicate that the addition of noncontractile material to a damaged left ventricular wall has important effects on cardiac mechanics, with potentially beneficial reduction of elevated myofiber stresses, as well as confounding changes to clinicalleft ventricular metrics.
Journal ArticleDOI
The Living Heart Project: A robust and integrative simulator for human heart function.
TL;DR: A proof-of-concept simulator for a four-chamber human heart model created from computer topography and magnetic resonance images is presented to explore and understand the key features, physics, and technologies to create an integrative, predictive model of the living human heart.
Journal ArticleDOI
Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling.
Lepeng Zeng,Qingsong Hu,Xiaohong Wang,Abdul Mansoor,Joseph Lee,Julia Feygin,Ge Zhang,Piradeep Suntharalingam,Sherry Boozer,Abner M. Mhashilkar,Carmelo J. Panetta,Cory Swingen,Robert J. Deans,Arthur H. L. From,Robert J. Bache,Catherine M. Verfaillie,Jianyi Zhang +16 more
TL;DR: Allogeneic pMultistem improved BZ energetics, regional contractile performance, and global left ventricular ejection fraction and may have resulted from paracrine effects that include increased vascular density in the BZ and spared myocytes in the infarct zone.
Journal ArticleDOI
Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation
Roy C. P. Kerckhoffs,Maxwell Lewis Neal,Quan Gu,James B. Bassingthwaighte,Jeffrey H. Omens,Andrew D. McCulloch +5 more
TL;DR: A novel, robust method to couple finite element models of cardiac mechanics to systems models of the circulation, independent of cardiac phase is presented, encompassing levels from cell to system.
Journal ArticleDOI
Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery
Sethuraman Sankaran,Mahdi Esmaily Moghadam,Andrew M. Kahn,Elaine E. Tseng,Julius M. Guccione,Alison L. Marsden +5 more
TL;DR: A computational framework for multiscale modeling and simulation of blood flow in coronary artery bypass graft (CABG) patients is presented and it is observed that PV loops do not change significantly after CABG but that both coronary perfusion and local hemodynamic parameters near the anastomosis region change substantially.
References
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Journal ArticleDOI
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.
Marc A. Pfeffer,Eugene Braunwald +1 more
TL;DR: The extent of ventricular enlargement after infarction is related to the magnitude of the initial damage to the myocardium and, although an increase in cavity size tends to restore stroke volume despite a persistently depressed ejection fraction, ventricular dilation has been associated with a reduction in survival.
Book ChapterDOI
Ventricular Remodeling after Myocardial Infarction
TL;DR: The extent of ventricular enlargement after infarction is related to the magnitude of the initial damage to the myocardium and, although an increase in cavity size tends to restore stroke volume despite a persistently depressed ejection fraction, ventricular dilation has been associated with a reduction in survival.
Journal ArticleDOI
Passive material properties of intact ventricular myocardium determined from a cylindrical model.
TL;DR: The results indicate that torsion, residual stress and material anisotropy associated with the fiber architecture all can act to reduce endocardial stress gradients in the passive left ventricle.
Journal ArticleDOI
Finite element stress analysis of left ventricular mechanics in the beating dog heart
TL;DR: There may be significant regional nonhomogeneity of fiber stress in the normal left ventricle associated with regional variations in shape and fiber angle, unlike in the midventricle region that has been studied most fully.
Journal ArticleDOI
Surgical anterior ventricular endocardial restoration (SAVER) in the dilated remodeled ventricle after anterior myocardial infarction
Constantine L. Athanasuleas,Alfred W.H. Stanley,Gerald D. Buckberg,Vincent Dor,Marissa DiDonato,Eugene H. Blackstone +5 more
TL;DR: Surgical anterior ventricular endocardial restoration is a safe and effective operation in the treatment of the remodeled dilated anterior ventricle after anterior myocardial infarction.