Journal ArticleDOI
Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells
Isil Altintas,Raimond Heukers,Roy van der Meel,Marie Lacombe,Maryam Amidi,Paul M.P. van Bergen en Henegouwen,Wim E. Hennink,Raymond M. Schiffelers,Robbert J. Kok +8 more
TLDR
The results demonstrate that multikinase inhibitor loaded nanoparticles are interesting nanomedicines for the treatment of EGFR-positive cancers.About:
This article is published in Journal of Controlled Release.The article was published on 2013-01-28. It has received 87 citations till now. The article focuses on the topics: Targeted drug delivery & Drug carrier.read more
Citations
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The Therapeutic Potential of Nanobodies
TL;DR: Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
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Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics.
TL;DR: Recent developments and perspectives for applications of nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics are discussed.
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Nanobodies as therapeutics: big opportunities for small antibodies
TL;DR: How Nbs are being explored as therapeutics in many fields of medicine, including oncology, inflammatory, infectious and neurological diseases, and imaging, is discussed and their potential for use in the diagnosis and monitoring of diseases is highlighted.
Journal ArticleDOI
Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery.
Feifei An,Xiaohong Zhang +1 more
TL;DR: This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.
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Albumin and its application in drug delivery
TL;DR: The FcRn receptor has additional functionality, especially in relation to immunology, antigen presentation and delivery of proteins across mucosal membranes, consequently albumin-based fusions and conjugates may have a future role in oral and pulmonary-based vaccines and drug delivery.
References
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Journal ArticleDOI
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.
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Albumin-based nanoparticles as potential controlled release drug delivery systems.
TL;DR: The current review embodies an in-depth discussion of albumin nanoparticles with respect to types, formulation aspects, major outcomes of in vitro and in vivo investigations as well as site-specific drug targeting using various ligands modifying the surface of albumins with special insights to the field of oncology.
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Advances in polymeric micelles for drug delivery and tumor targeting.
TL;DR: This review summarizes recently available information regarding targeting of anticancer drugs to the tumor site using PMs.
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Endocytosis and intracellular trafficking of ErbBs.
Alexander Sorkin,Lai Kuan Goh +1 more
TL;DR: This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family and the role of EGFR interaction with the Grb2 adaptor protein and Cbl ubiquitin ligase, and receptor ubiquitination in the clathrin-dependent internalization and sorting of EG FR in multivesicular endosomes.
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Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
TL;DR: A pump-controlled preparation method was established which enabled particle preparation under defined conditions and the reproducibility of the particle size and particle size distribution under the proposed preparation conditions was demonstrated.