Neutrophils cascading their way to inflammation
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TLDR
Current data suggest that neutrophil chemoattractants have unique functions in the recruitment of neutrophils into inflammatory sites in vivo, dictated by their distinct patterns of temporal and spatial expression.About:
This article is published in Trends in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 486 citations till now. The article focuses on the topics: Innate immune system.read more
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Book ChapterDOI
Chapter 45 – The Neutrophil
Nancy A. Louis,Charles A. Parkos +1 more
TL;DR: Neutrophils represent the first responders of the innate immune system and possess an array of powerful biological weapons including soluble mediators as well as a capacity for phagocytosis of pathogens and microbial killing.
Understanding the human innate immune system : In-silico studies
TL;DR: By incorporating Alkaline Phosphatase (AP) in modelling HIIS, it is shown that AP has a pivotal role in neutralizing inflammation in patients undergoing cardiac surgery and pinpoint and quantify the driving mechanisms on how neutrophils pick a death pathway in response to various levels of ITMs.
Journal ArticleDOI
Neutrophil Migratory Patterns: Implications for Cardiovascular Disease
Albert Dahdah,Jillian Johnson,Sreejit Gopalkrishna,Robert M. Jaggers,Darren C. Webb,Andrew J. Murphy,Nordin M J Hanssen,Beatriz Y. Hanaoka,Prabhakara R Nagareddy +8 more
TL;DR: The current consensus on the mechanisms involved in leukocyte margination and demargination are presented, with a focus on the role of neutrophil migration patterns during physio-pathological conditions, in particular diabetes and cardiovascular disease.
Journal ArticleDOI
Protective effects of Ficus carica seed oil on ischemia and reperfusion injury in a rat model of acute mesenteric ischemia.
TL;DR: Oral administration of fig seed oil may reverse biochemical and histopathological findings resulting from ischemia-reperfusion injury in an experimental model of acute mesenteric ischemIA in rats, probably because of its antioxidant and anti-inflammatory compounds.
Trauma and Cytokines: Gingival Crevicular Fluid Biomarkers in Traumatized Permanent Incisors - A Pilot Investigation
TL;DR: If any variation exists between normal healing and pathology in traumatized teeth in growing children that could lead to early predictors of pathology, this could help to decrease cost and time for patients and their families.
References
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Journal ArticleDOI
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
Journal ArticleDOI
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg,Fanny Chu,Soraya Utokaparch,Ryan Woods,W. Mark Elliott,Liliana Buzatu,Ruben M. Cherniack,Robert M. Rogers,Frank C. Sciurba,Harvey O. Coxson,Peter D. Paré +10 more
TL;DR: Progression of COPD is associated with the accumulation of inflammatory mucous exudates in the lumen and infiltration of the wall by innate and adaptive inflammatory immune cells that form lymphoid follicles, coupled to a repair or remodeling process that thickens the walls of these airways.
Journal ArticleDOI
How neutrophils kill microbes
TL;DR: Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase, but this is incorrect.
Journal ArticleDOI
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V. Serbina,Eric G. Pamer +1 more
TL;DR: In blood, Ccr2−/− monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues, and determining the frequency of Ly6Chi monocytes in the circulation.
Journal ArticleDOI
Neutrophils, from marrow to microbes.
TL;DR: Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules that contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage.