Neutrophils cascading their way to inflammation
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TLDR
Current data suggest that neutrophil chemoattractants have unique functions in the recruitment of neutrophils into inflammatory sites in vivo, dictated by their distinct patterns of temporal and spatial expression.About:
This article is published in Trends in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 486 citations till now. The article focuses on the topics: Innate immune system.read more
Citations
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Journal ArticleDOI
The Role of the Immune Cells in Fracture Healing.
TL;DR: The functional role of immune cells as it pertains to bone fracture healing is discussed and the cytokines secreted and their effects within the healing fracture callus are outlined.
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β2 Integrin–Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood–Brain Barrier
TL;DR: It is demonstrated that neutrophil arrest, polarization, and crawling required G-protein–coupled receptor–dependent activation of β2 integrins and binding to endothelial ICAM-1 andICAM-2 is a prerequisite for transcellular neutrophils diapedesis across the inflamed BBB.
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Critical role for MyD88-mediated neutrophil recruitment during Clostridium difficile colitis.
TL;DR: It is demonstrated that MyD88-mediated signals trigger neutrophil and CCR2-dependent Ly6Chi monocyte recruitment to the colonic lamina propria (cLP) during infection, which prevent dissemination of bystander bacteria to deeper tissues.
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Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
TL;DR: Findings support the concept that immune complex-mediated leukocyte activation is not composed of overlapping and redundant pathways, but that each element serves a distinct and critical function in vivo, culminating in tissue inflammation.
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Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture
Atsushi Anzai,Masayuki Shimoda,Jin Endo,Takashi Kohno,Yoshinori Katsumata,Tomohiro Matsuhashi,Tsunehisa Yamamoto,Kentaro Ito,Xiaoxiang Yan,Kohsuke Shirakawa,Ryoko Shimizu-Hirota,Yoshitake Yamada,Satoshi Ueha,Ken Shinmura,Yasunori Okada,Keiichi Fukuda,Motoaki Sano +16 more
TL;DR: Investigating the underlying mechanisms of catastrophic complications after acute aortic dissection in mice found Adventitial CXCL1/granulocyte-colony stimulating factor expression in response to AAD triggers local neutrophil recruitment and activation, which leads to adventitial inflammation via IL-6 and results in aorti expansion and rupture.
References
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
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The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg,Fanny Chu,Soraya Utokaparch,Ryan Woods,W. Mark Elliott,Liliana Buzatu,Ruben M. Cherniack,Robert M. Rogers,Frank C. Sciurba,Harvey O. Coxson,Peter D. Paré +10 more
TL;DR: Progression of COPD is associated with the accumulation of inflammatory mucous exudates in the lumen and infiltration of the wall by innate and adaptive inflammatory immune cells that form lymphoid follicles, coupled to a repair or remodeling process that thickens the walls of these airways.
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How neutrophils kill microbes
TL;DR: Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase, but this is incorrect.
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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V. Serbina,Eric G. Pamer +1 more
TL;DR: In blood, Ccr2−/− monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues, and determining the frequency of Ly6Chi monocytes in the circulation.
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Neutrophils, from marrow to microbes.
TL;DR: Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules that contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage.