Neutrophils cascading their way to inflammation
Reads0
Chats0
TLDR
Current data suggest that neutrophil chemoattractants have unique functions in the recruitment of neutrophils into inflammatory sites in vivo, dictated by their distinct patterns of temporal and spatial expression.About:
This article is published in Trends in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 486 citations till now. The article focuses on the topics: Innate immune system.read more
Citations
More filters
Journal ArticleDOI
G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling
Besnik Bajrami,Haiyan Zhu,Hyun-Jeong Kwak,Hyun-Jeong Kwak,Subhanjan Mondal,Subhanjan Mondal,Qingming Hou,Qingming Hou,Guangfeng Geng,Kutay Karatepe,Kutay Karatepe,Yu C. Zhang,Yu C. Zhang,César Nombela-Arrieta,Shin-Young Park,Shin-Young Park,Fabien Loison,Fabien Loison,Jiro Sakai,Jiro Sakai,Yuanfu Xu,Leslie E. Silberstein,Leslie E. Silberstein,Hongbo R. Luo,Hongbo R. Luo +24 more
TL;DR: It is reported that CXCR2 ligands are responsible for rapid neutrophil mobilization during early-stage acute inflammation and that G-CSF suppresses this mobilization by negatively regulating CX CR2-mediated intracellular signaling.
Journal ArticleDOI
Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.
TL;DR: The blockade of neutrophil recruitment at early ages using CXCR2 antagonist dampens the diabetogenic T‐cell response and the later development of autoimmune diabetes, supporting the therapeutic potential of this approach.
Journal ArticleDOI
Dysregulated immune system networks in war veterans with PTSD is an outcome of altered miRNA expression and DNA methylation.
Marpe Bam,Xiaoming Yang,Elizabeth E. Zumbrun,Yin Zhong,Juhua Zhou,Jay P. Ginsberg,Quinne Leyden,Jiajia Zhang,Prakash S. Nagarkatti,Mitzi Nagarkatti +9 more
TL;DR: Combining data from the three techniques provided a holistic view of several pathways in which the differentially expressed genes were impacted through epigenetic mechanisms, in PTSD, providing further evidence that inflammation in PTSD could be epigenetically regulated.
Journal ArticleDOI
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection
Mohammad Arifuzzaman,Yuvon R. Mobley,Hae Woong Choi,Pradeep Bist,Cristina A Salinas,Zachary D. Brown,Swaine L. Chen,Swaine L. Chen,Herman F. Staats,Soman N. Abraham +9 more
TL;DR: Topical treatment with mastoparan, a peptide MC activator (MCA), enhances clearance of Staphylococcus aureus from infected mouse skins and accelerates healing of dermonecrotic lesions and reinforces protection against a second infection challenge.
Journal ArticleDOI
Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain
Eleonora U Carreira,Vanessa Carregaro,Mauro M. Teixeira,Alessio Moriconi,Andrea Aramini,Waldiceu A. Verri,S H Ferreira,Fernando Q. Cunha,Thiago M. Cunha +8 more
TL;DR: The function of neutrophils in the genesis of post‐incisional pain in an experimental model of post-surgical pain is addressed in a study on neutrophil migration and activation triggered by CXCL1‐CXCR1/2 signalling.
References
More filters
Journal ArticleDOI
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
Journal ArticleDOI
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg,Fanny Chu,Soraya Utokaparch,Ryan Woods,W. Mark Elliott,Liliana Buzatu,Ruben M. Cherniack,Robert M. Rogers,Frank C. Sciurba,Harvey O. Coxson,Peter D. Paré +10 more
TL;DR: Progression of COPD is associated with the accumulation of inflammatory mucous exudates in the lumen and infiltration of the wall by innate and adaptive inflammatory immune cells that form lymphoid follicles, coupled to a repair or remodeling process that thickens the walls of these airways.
Journal ArticleDOI
How neutrophils kill microbes
TL;DR: Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase, but this is incorrect.
Journal ArticleDOI
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V. Serbina,Eric G. Pamer +1 more
TL;DR: In blood, Ccr2−/− monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues, and determining the frequency of Ly6Chi monocytes in the circulation.
Journal ArticleDOI
Neutrophils, from marrow to microbes.
TL;DR: Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules that contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage.