Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.
Yu Rou Puar,Muthu K. Shanmugam,Lu Fan,Frank Arfuso,Gautam Sethi,Vinay Tergaonkar,Vinay Tergaonkar,Vinay Tergaonkar +7 more
TLDR
Although NF-κB has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-σB function.Abstract:
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation of a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. At the same time, this transcription factor can control the expression of a plethora of genes that promote tumor cell proliferation, survival, metastasis, inflammation, invasion, and angiogenesis. The aberrant activation of this transcription factor has been observed in several types of cancer and is known to contribute to aggressive tumor growth and resistance to therapeutic treatment. Although NF-κB has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression. This review briefly highlights the major mechanisms of NF-κB activation, the role of NF-κB in tumor promotion and suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-κB function.read more
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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements.
Vaishali Aggarwal,Hardeep Singh Tuli,Ayşegül Varol,Falak Thakral,Mükerrem Betül Yerer,Katrin Sak,Mehmet Varol,Aklank Jain,Md. Asaduzzaman Khan,Gautam Sethi +9 more
TL;DR: The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously.
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Potential effects of curcumin in the treatment of COVID-19 infection.
Fatemeh Zahedipour,Seyede Atefe Hosseini,Thozhukat Sathyapalan,Muhammed Majeed,Tannaz Jamialahmadi,Tannaz Jamialahmadi,Khalid Al-Rasadi,Maciej Banach,Maciej Banach,Amirhossein Sahebkar,Amirhossein Sahebkar +10 more
TL;DR: Some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways are reviewed.
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Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?
Sepideh Mirzaei,Ali Zarrabi,Farid Hashemi,Amirhossein Zabolian,Hossein Saleki,Adnan Ranjbar,Seyed Hesam Seyed Saleh,Morteza Bagherian,Seyed Omid Sharifzadeh,Kiavash Hushmandi,Alena Liskova,Peter Kubatka,Pooyan Makvandi,Vinay Tergaonkar,Alan Prem Kumar,Milad Ashrafizadeh,Gautam Sethi +16 more
TL;DR: In this paper, it has been shown that microRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells.
Journal ArticleDOI
Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.
Milad Ashrafizadeh,Ali Zarrabi,Kiavash Hushmandi,Kiavash Hushmandi,Mahshad Kalantari,Reza Mohammadinejad,Tahereh Javaheri,Gautam Sethi +7 more
TL;DR: The various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure are highlighted.
Journal ArticleDOI
Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis.
Muthu K. Shanmugam,Kwang Seok Ahn,Annie Hsu,Chern Chiuh Woo,Yi Yuan,Kwong Huat Benny Tan,Arunachalam Chinnathambi,Tahani Awad Alahmadi,Sulaiman Ali Alharbi,Angele Pei-Fern Koh,Frank Arfuso,Ruby Yun-Ju Huang,Lina H. K. Lim,Gautam Sethi,Alan Prem Kumar +14 more
TL;DR: The results indicate that TQ primarily exerts its anti-metastatic effects by down-regulation of NF-κB regulated CXCR4 expression and thus has potential for the treatment of breast cancer.
References
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