Journal ArticleDOI
Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132
TLDR
In this article, Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina, was identified.Abstract:
Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.read more
Citations
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Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger , Aspergillus oryzae , and Trichoderma reesei
TL;DR: This review presents an update on the current knowledge of the secondary metabolite potential of the major fungal species used in industrial biotechnology, i.e., Aspergillus niger, As pergillus oryzae, and Trichoderma reesei, and a description of all known secondary metabolites produced by these species.
Journal ArticleDOI
Marine Fungi: A Source of Potential Anticancer Compounds.
TL;DR: The majority of anticancer compounds isolated from marine fungi during 2012–2016 against specific cancer cell lines are reviewed to cover their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them.
Journal ArticleDOI
Antibacterial and Antifungal Compounds from Marine Fungi
TL;DR: The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.
Journal ArticleDOI
Bioactive natural products derived from mangrove-associated microbes
TL;DR: This review summarizes new findings concerning the sources and characteristics of various natural products that can be extracted from mangrove-associated microbes over the past three years with a focus on bioactivity.
Journal ArticleDOI
Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina.
TL;DR: Six new disulfide-bridged diketopiperazine derivatives, brocazines A-F (1-6), along with one known analogue (7), were isolated and identified from the cytotoxic extract of Penicillium brocae MA-231, a fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina.
References
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Secondary metabolites of fungi from marine habitats.
TL;DR: An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.
Journal ArticleDOI
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.
Yvonne P. Keepers,Paulo E. Pizao,Godefridus J. Peters,Jannette van Ark-Otte,B. Winograd,B. Winograd,Herbert M. Pinedo +6 more
TL;DR: The sulforhodamine B (SRB) protein stain assay was compared with the tetrazolium (MTT) colorimetric assay for in vitro chemosensitivity testing of various human tumour cell lines and provided a better linearity with cell number and a higher sensitivity.
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The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity.
TL;DR: The sulphorhodamine B (SRB) assay is described in detail as the preferred method and a novel approach has been developed which is based on the hypothesis that, in some circumstances, the naturally occurring compounds act as prodrugs rather than active compounds in their own right.
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Rapid chemosensitivity testing of human lung tumor cells using the MTT assay.
TL;DR: A rapid and efficient colorimetric assay for testing the chemosensitivity of human lung tumor cells by converting tetrazolium salt to a colored formazan product by enzymes active only in living cells.
Journal ArticleDOI
Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata
Song Wang,Li Xiaoming,Franka Teuscher,Dong-Li Li,Arnulf Diesel,Rainer Ebel,Peter Proksch,Bin-Gui Wang +7 more
TL;DR: To the authors' knowledge, compound 1 represents the first example of a 2H-benzopyran derivative of marine algal-derived fungi as well as of the fungal genus Chaetomium, which exhibited moderate to weak cytotoxic activity toward several tumor cell lines.