Journal ArticleDOI
No association of G72 and d-amino acid oxidase genes with schizophrenia
Yu-Li Liu,Cathy S.J. Fann,Chih-Min Liu,Chien-Ching Chang,Jer-Yuarn Wu,Shuen-Iu Hung,Shih-Kai Liu,Ming H. Hsieh,Tzung-Jeng Hwang,Hung-Yu Chan,Jiahn-Jyh Chen,Stephen V. Faraone,Ming T. Tsuang,Ming T. Tsuang,Wei J. Chen,Hai-Gwo Hwu +15 more
TLDR
The genes of D-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-D-aspartate receptor regulation pathway for schizophrenia.About:
This article is published in Schizophrenia Research.The article was published on 2006-10-01. It has received 56 citations till now. The article focuses on the topics: Candidate gene & Single-nucleotide polymorphism.read more
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Book ChapterDOI
Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
TL;DR: Clinical challenge studies with PCP and ketamine have confirmed the close resemblance between NMDA antagonist-induced symptoms and neurocognitive deficits and those observed in schizophrenia, and suggest that NMDA dysfunction may lead to secondary dopaminergic dysregulation in striatal and prefrontal brain regions.
Journal ArticleDOI
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?
TL;DR: The N MDAR complex represents a convergence point for potential new treatment approaches in schizophrenia aimed at correcting underlying abnormalities in synthesis and regulation of allosteric modulators, as well as more general potentiation of pre- and post-synaptic glutamatergic and NMDAR function.
Journal ArticleDOI
Molecular mechanisms of schizophrenia.
TL;DR: Molecular findings suggest that a complex interplay between receptors, kinases, proteins and hormones is involved in schizophrenia and in a unifying hypothesis, different cascades merge into another that ultimately lead to the development of symptoms adherent to schizophrenic disorders.
Journal ArticleDOI
d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia.
Louise Verrall,M A Walker,Nancy B. Rawlings,Isabel Benzel,James N.C. Kew,Paul Harrison,Philip W.J. Burnet +6 more
TL;DR: These findings establish the major cell types wherein serine racemase and d‐amino acid oxidase are expressed in human brain and provide some support for aberrant d‐serine metabolism in schizophrenia, but raise further questions as to the roles of d‐Amino acid oxidationase and serine Racemase in both physiological and pathophysiological processes in the brain.
Journal ArticleDOI
The neurobiology of D -amino acid oxidase and its involvement in schizophrenia
TL;DR: This review critically review the neurobiology of DAO, its involvement in schizophrenia, and the therapeutic value ofDAO inhibition and highlights issues that have a broader relevance beyond DAO itself.
References
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Journal ArticleDOI
PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis
TL;DR: Four error-checking algorithms are implemented in a new computer program, PedCheck, which will assist researchers in identifying all Mendelian inconsistencies in pedigree data and will provide them with useful and detailed diagnostic information to help resolve the errors.
Journal ArticleDOI
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.
TL;DR: The results of these investigations were sufficient to show that even for relatively simple cases (two loci, simple symmetrical selective values) linkage might have profound effects on the course of natural selection and, pari passu, natural selection may have major effect on the distribution of coupling and repulsion linkage in a population.
Journal Article
Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.
Eric M. Sobel,Kenneth Lange +1 more
TL;DR: Algorithms for implementing Thompson's suggestion for codominant markers in the context of automatic haplotyping, estimating location scores, and computing gene-clustering statistics for robust linkage analysis are explored.
Journal ArticleDOI
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.
Ilya Chumakov,Marta Blumenfeld,Oxana Guerassimenko,Laurent Cavarec,Marta Palicio,Hadi Abderrahim,Lydie Bougueleret,C Barry,Hiroaki Tanaka,Philippe La Rosa,Anne Puech,Nadia Tahri,Annick Cohen-Akenine,Sylvain Delabrosse,Sébastien Lissarrague,Françoise-Pascaline Picard,Karelle Maurice,Laurent Essioux,Philippe Millasseau,Pascale Grel,Virginie Debailleul,Anne-Marie Simon,Dominique Caterina,Isabelle Dufaure,Kattayoun Malekzadeh,Maria Belova,Jian-Jian Luan,Michel Bouillot,Jean-Luc Sambucy,Gwenael Primas,Martial Saumier,Nadia Boubkiri,Sandrine Martin-Saumier,Myriam Nasroune,Hélène Peixoto,A Delaye,Virginie Pinchot,Mariam Bastucci,Sophie Guillou,Magali Chevillon,Ricardo Sainz-Fuertes,Said Meguenni,Joan Aurich-Costa,Dorra Cherif,Anne Gimalac,Cornelia M. van Duijn,Denis Gauvreau,Gail Ouelette,Isabel Fortier,John Realson,Tatiana Sherbatich,Nadejda Riazanskaia,Evgeny I. Rogaev,Peter Raeymaekers,Jeroen Aerssens,Frank Konings,Walter Luyten,Fabio Macciardi,Pak C. Sham,Richard E. Straub,Daniel R. Weinberger,Nadine Cohen,Daniel Cohen +62 more
TL;DR: A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia, pointing to the involvement of this N-methyl-d-aspartate receptor regulation pathway in schizophrenia.
Journal ArticleDOI
GOLD—Graphical Overview of Linkage Disequilibrium
TL;DR: A software package that provides a graphical summary of linkage disequilibrium in human genetic data that allows for theAnalysis of family data and is well suited to the analysis of dense genetic maps is described.
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Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.
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