Journal ArticleDOI
Novel advancements in the management of hepatocellular carcinoma in 2008
Josep M. Llovet,Jordi Bruix +1 more
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TLDR
Sorafenib, a multikinase inhibitor, has shown survival benefits in patients at advanced stages of the disease, and proves that molecular targeted therapies can be effective in this otherwise chemo-resistant tumor.About:
This article is published in Journal of Hepatology.The article was published on 2008-01-01. It has received 804 citations till now. The article focuses on the topics: Sorafenib.read more
Citations
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EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma European Association for the Study of the Liver ⇑ , European Organisation for Research and Treatment of Cancer
Josep M. Llovet,Michel Ducreux,Riccardo Lencioni,Adrian M. Di Bisceglie,Jean-Francois J. DuFour,Tim F. Greten,Eric Raymond,Tania Roskams,Vincenzo Mazzaferro,Jordi Bruix,Massimo Colombo,Andrew X. Zhu +11 more
TL;DR: The purpose of this document is to assist physicians, patients, health-care providers, and health-policy makers from Europe and worldwide in the decision-making process according to evidencebased data.
Journal ArticleDOI
Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update
Masao Omata,Ann-Lii Cheng,Norihiro Kokudo,Masatoshi Kudo,Jeong Min Lee,Jidong Jia,Ryosuke Tateishi,Kwang Hyub Han,Yoghesh K. Chawla,Shuichiro Shiina,Wasim Jafri,Diana A. Payawal,Takamasa Ohki,Sadahisa Ogasawara,Pei-Jer Chen,Cosmas Rinaldi Adithya Lesmana,Laurentius A. Lesmana,Rino Alvani Gani,Shuntaro Obi,A. Kadir Dokmeci,Shiv Kumar Sarin +20 more
TL;DR: The latest guidelines for the treatment of HCC recommend evidence-based management and are considered suitable for universal use in the Asia–Pacific region, which has a diversity of medical environments.
Journal ArticleDOI
Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma
Yujin Hoshida,Augusto Villanueva,Masahiro Kobayashi,Judit Peix,Derek Y. Chiang,Amy L. Camargo,Supriya Gupta,Jamie Moore,Matthew J. Wrobel,Jim Lerner,Michael R. Reich,Jennifer A. Chan,Jonathan N. Glickman,Kenji Ikeda,Masaji Hashimoto,Goro Watanabe,Maria Grazia Daidone,Sasan Roayaie,Myron Schwartz,Swan N. Thung,Helga B. Salvesen,Stacey Gabriel,Vincenzo Mazzaferro,Jordi Bruix,Scott L. Friedman,Hiromitsu Kumada,Josep M. Llovet,Todd R. Golub +27 more
TL;DR: The feasibility of genomewide expression profiling of formalin-fixed, paraffin-embedded tissues is demonstrated and it is shown that a reproducible gene-expression signature correlated with survival is present in liver tissue adjacent to the tumor in patients with hepatocellular carcinoma.
Journal ArticleDOI
Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma.
Masao Omata,Laurentius A. Lesmana,Ryosuke Tateishi,Pei-Jer Chen,Shi-Ming Lin,Haruhiko Yoshida,Masatoshi Kudo,Jeong Min Lee,Byung Ihn Choi,Ronnie T.P. Poon,Shuichiro Shiina,Ann-Lii Cheng,Ji Dong Jia,Shuntaro Obi,Kwang Hyub Han,Wasim Jafri,Pierce K. H. Chow,Seng Gee Lim,Yogesh Chawla,Unggul Budihusodo,Rino Alvani Gani,C. Rinaldi A. Lesmana,Terawan Agus Putranto,Yun Fan Liaw,Shiv Kumar Sarin +24 more
TL;DR: Recommendations on the management of hepatocellular carcinoma were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.
Journal ArticleDOI
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial.
Jordi Bruix,Jean-Luc Raoul,Morris Sherman,Vincenzo Mazzaferro,Luigi Bolondi,Antonio Craxì,Peter R. Galle,Armando Santoro,Michel Beaugrand,Angelo Sangiovanni,Camillo Porta,Guido Gerken,Jorge A. Marrero,Andrea Nadel,Michael Shan,M. Moscovici,D. Voliotis,Josep M. Llovet +17 more
TL;DR: The SHARP trial as discussed by the authors showed that sorafenib consistently improved median OS and DCR compared with placebo in patients with advanced HCC, irrespective of disease etiology, baseline tumor burden, performance status, tumor stage and prior therapy.
References
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Vincenzo Mazzaferro,Enrico Regalia,Roberto Doci,Salvatore Andreola,A. Pulvirenti,Federico Bozzetti,F. Montalto,Mario Ammatuna,Alberto Morabito,Leandro Gennari +9 more
TL;DR: Liver transplantation is an effective treatment for small, unresectable hepatocellular carcinomas in patients with cirrhosis and after four years, the actuarial survival rate was 75 percent and the rate of recurrence-free survival was 83 percent.
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The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Igor Vivanco,Charles L. Sawyers +1 more
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Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
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Related Papers (5)
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more