Journal ArticleDOI
Nutrients in the fate of pluripotent stem cells
TLDR
In this paper, the available data on nutrients and their metabolic conversion that influence pluripotent stem cell fates are evaluated, and key questions open for investigation in this rapidly expanding area of increasing fundamental and practical importance.About:
This article is published in Cell Metabolism.The article was published on 2021-11-02. It has received 13 citations till now. The article focuses on the topics: Induced pluripotent stem cell.read more
Citations
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Journal ArticleDOI
Metabolic regulation of somatic stem cells in vivo
TL;DR: Better understanding of metabolic regulation in stem cells will open new opportunities to manipulate stem cell function, with potential applications in tissue regeneration and cancer prevention.
Journal ArticleDOI
Metabolic regulation of somatic stem cells in vivo
Journal ArticleDOI
Role of Diet in Stem and Cancer Stem Cells
TL;DR: A deep understanding of the specific dietetic requirements of normal and cancer stem cells may pave the way for the development of nutrition-based targeted therapeutic approaches to improve regenerative and anticancer therapies.
Journal ArticleDOI
Metabolic regulation in pluripotent stem cells.
Linda Diamante,Graziano Martello +1 more
TL;DR: The metabolic requirements of PSCs are investigated in this article , showing that metabolism plays an instructive role on PSC behavior. But the metabolic requirements are not directly regulated by exogenous stimuli or nutrient availability in PSC, as key pluripotency regulators, such as Oct4, Stat3 and Tfcp2l1, actively shape the metabolic profile of Pscs.
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Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
Manuele Rebsamen,Enrico Girardi,Vitaly Sedlyarov,Stefania Scorzoni,Konstantinos Papakostas,Manuela Vollert,Justyna Konecka,Bettina Guertl,Kristaps Klavins,Tabea Wiedmer,Giulio Superti-Furga +10 more
TL;DR: This gain-of-function approach to identify human SLCs able to sustain cell viability and proliferation under growth-limiting concentrations of essential nutrients led to the definition of functional transporter-nutrient relationships and revealed that upregulation of transport activity may be sufficient to overcome environmental metabolic restrictions.
References
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Journal ArticleDOI
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI
mTOR Signaling in Growth, Metabolism, and Disease.
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.
Journal ArticleDOI
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Yasemin Sancak,Timothy R. Peterson,Yoav D. Shaul,Robert A. Lindquist,Carson C. Thoreen,Liron Bar-Peled,David M. Sabatini,David M. Sabatini +7 more
TL;DR: It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
Journal ArticleDOI
Autophagy and metabolism.
TL;DR: A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases and does have a downside, however—cancer cells exploit it to survive in nutrient-poor tumors.
Journal ArticleDOI
Regulation of TORC1 by Rag GTPases in nutrient response.
TL;DR: Genetic studies in Drosophila show that Rag GTPases regulate cell growth, autophagy and animal viability during starvation, and establish a function of Rag G TPases in TORC1 activation in response to amino acid signals.