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O colágeno em fáscia transversal de pacientes com hérnia inguinal direta submetidos à videolaparoscopia

TLDR
The direct inguinal hernia patients have less collagen in transversalis fascia either absolutely or relatively to other constitutional elements, stablishing that there are less collagenIn the hernia's wall.
Abstract
OBJETIVO: Analisar quanto a espessura, elementos constitutivos e quantificacao do colageno total amostras de fascias transversais de pacientes entre 20 e 60 anos de idade, com hernia inguinal direta, coletadas no momento da correcao videolaparoscopica, comparando-as com amostras do mesmo tecido, retiradas de cadaveres. METODOS: Biopsias de 23 pacientes e de 22 cadaveres foram analisadas e comparadas. Utilizaram-se as tecnicas de coloracao de Hematoxilina-Eosina e Picrosirius. As imagens captadas foram analisadas por tecnica videomorfometrica assistida por computador. RESULTADOS: Constatou-se uma espessura de fascia transversal nos controles, em media, de 4.5 milimetros. A espessura da fascia transversal dos pacientes com hernia foi, em media, 58 % menor (p< 0.001). Nao se evidenciou algum processo de degeneracao das fibras de colageno atribuivel a senilidade. O principal elemento constitutivo da fascia, nos dois grupos, foi o tecido conjuntivo denso, representando cerca de 75 % nos controles e sendo um terco menor nos pacientes (p< 0.001). A area media percentual de colageno no campo amostral dos pacientes encontrada foi metade da area dos controles (p< 0.001), resultando em uma menor quantidade de colageno na parede posterior herniada. CONCLUSAO: Os pacientes com hernia inguinal direta apresentam menor quantidade de colageno tanto absoluta quanto relativamente aos demais elementos constitutivos da fascia transversal.

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Journal ArticleDOI

Etiology of inguinal hernia: ultrastructure of rectus sheath revisited.

TL;DR: The theory linking connective tissue alterations with the etiology of hernia, and stating that these alterations include connectives tissue at locations distant from the hernia site as well, is supported, as the rectus sheath itself does not form a hernial defect.
Journal ArticleDOI

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

TL;DR: Collagen was first seen on the 3rd day post-implantation, with a higher percentage of type I collagen at the last observational time point, and the prolonged healing inflammatory response and the persistence of chronic inflammation surrounding to the mesh did not affect the length of time required for fibroplasia.
Journal ArticleDOI

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients.

TL;DR: An increase in the quantity of collagen type III was found in patients with inguinal hernia and a greater quantity in those patients classified with Nyhus IIIa, and there is no significant difference in the quality of collagen in the fascia transversalis of patients compared to the controls.
Journal ArticleDOI

Qualitative and quantitative evaluation of total and types I and III collagens in patients with ventral hernias

TL;DR: The results of this study indicate a relationship between hernias of the anterior abdominal wall and smaller amounts of total and type I collagens.
References
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Journal ArticleDOI

Metastatic emphysema a mechanism for acquiring inguinal herniation

TL;DR: The results indicate that an imbalance between blood proteases and antiproteases, resulting from chronic smoking can damage connective tissue in the groin as well as the lung.
Journal ArticleDOI

Study of biochemical substrate and role of metalloproteinases in fascia transversalis from hernial processes

TL;DR: The fascia transversalis from patients presenting direct hernia showed a very strong staining vs. metalloproteinase‐2 when compared with that observed in indirect hernia, and the interfibrillar matrix was more abundant in direct hernias, showing abundant electron‐dense particles.
Journal ArticleDOI

Attenuation of the rectus sheath in inguinal herniation.

TL;DR: Results indicate that in inguinal herniation the rectus sheath unrelated to the defect is thinner than normal, and a patent processus vaginalis allows herniated with less atrophy than in direct defects.