Journal ArticleDOI
Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study
Marc Decramer,Kenneth R. Chapman,Ronald Dahl,Peter Frith,Gilles Devouassoux,Carlos Cezar Fritscher,Ray Cameron,Muhammad Shoaib,David Lawrence,David Young,Danny McBryan +10 more
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TLDR
Indacaterol and tiotropium provided clinically relevant improvements in lung function with comparable safety profiles and the present data offer evidence consistent with current guidelines.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2013-09-01. It has received 230 citations till now. The article focuses on the topics: Tiotropium bromide & Indacaterol.read more
Citations
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Acute exacerbations of chronic obstructive lung disease
TL;DR: Patients with two or more exacerbations treated in the outpatient department are considered as frequent exacerbators – the phenotype associated with poorer quality of life and accelerated loss of lung function.
Journal ArticleDOI
The efficacy and safety of additional treatment with short-acting muscarinic antagonist combined with long-acting beta-2 agonist in stable patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Kazuya Tanimura,Susumu Sato,Yukio Fujita,Yoshifumi Yamamoto,Takashi Hajiro,Nobuyuki Horita,Tomotaka Kawayama,Shigeo Muro +7 more
TL;DR: In this article , the authors conducted a systematic review and meta-analysis to evaluate the efficacy and safety of a short-acting muscarinic antagonist (SAMA) therapy combined with a long-acting beta-2 agonist (LABA) in patients with stable COPD.
Journal ArticleDOI
Bioequivalence of Two Tiotropium Dry Powder Inhalers and the Utility of Realistic Impactor Testing.
TL;DR: In this paper , a series of five pharmacokinetic (PK) studies comparing a generic tiotropium dry powder inhaler (DPI) to Spiriva HandiHaler, the realistic in vitro methods used to support those studies, and the related in vitro-in vivo correlations (IVIVCs).
Bronchodilators: the cornerstone of COPD therapy
TL;DR: It seems that a LAMA offers some advantages compared to a LABA, as both classes of drugs seem to be equally well tolerated at initiation of therapy.
Journal ArticleDOI
Ein LAMA ist bei therapienaiven Patienten ein guter Einstieg
TL;DR: In this paper, Dr. Marco Idzko aus Wien empfahl eine Vorgehensweise nach Symptomschwere und Eosinophilenzahl im Blut.
References
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
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A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
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The St George's Respiratory Questionnaire.
TL;DR: The St George's Respiratory Questionnaire is a standardized self-completed questionnaire for measuring impaired health and perceived well-being in airways disease and the background and rationale for its development are discussed together with an analysis of its performance.
Journal ArticleDOI
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
TL;DR: It is suggested that the frequency of exacerbations contributes to long term decline in lung function of patients with moderate to severe COPD.