Journal ArticleDOI
Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study
Marc Decramer,Kenneth R. Chapman,Ronald Dahl,Peter Frith,Gilles Devouassoux,Carlos Cezar Fritscher,Ray Cameron,Muhammad Shoaib,David Lawrence,David Young,Danny McBryan +10 more
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TLDR
Indacaterol and tiotropium provided clinically relevant improvements in lung function with comparable safety profiles and the present data offer evidence consistent with current guidelines.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2013-09-01. It has received 230 citations till now. The article focuses on the topics: Tiotropium bromide & Indacaterol.read more
Citations
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Journal ArticleDOI
Optimizing Treatment of Elderly COPD Patients: What Role for Inhaled Corticosteroids?
TL;DR: Regular use of ICS in more elderly patients with COPD should follow guideline recommendations, be considered with caution, and be based upon carefully weighing up expected benefits with the risk of undesired, adverse effects.
Journal ArticleDOI
Inhaled treatment of COPD : a Delphi consensus statement.
Vincent Ninane,Jean-Louis Corhay,Paul Germonpré,Wim Janssens,Guy Joos,Giuseppe Liistro,Walter Vincken,Sandra Gurdain,Evelyne Vanvlasselaer,An Lehouck +9 more
TL;DR: The level of medical experts’ consensus on their preferred first-choice treatment within different COPD categories was evaluated to recommend long-acting bronchodilators as first- Choice treatment.
Journal ArticleDOI
Cutting edge of COPD therapy: current pharmacological therapy and future direction
TL;DR: To establish novel COPD therapies that can considerably reduce the disease progression and mortality as well as the comorbidities associated with COPD, new therapeutic targets that are involved in the pathophysiology of COPD are being investigated.
Journal ArticleDOI
Indacaterol for the treatment of chronic obstructive pulmonary disease
TL;DR: As indacaterol/glycopyrronium fixed-dose combination (QVA149) shows superior efficacy compared to glycopyrronsium and tiotropium in patients with moderate to severe COPD, a fundamental question regarding the use of indac Caterol that requires clarification is whether it is preferable to start immediately with QVA149 rather than using indACaterol alone.
Journal ArticleDOI
Relationship Between FEV 1 and Patient-Reported Outcomes Changes: Results of a Meta-Analysis of Randomized Trials in Stable COPD.
de la Loge C,Tugaut B,Fofana F,Lambert J,Hennig M,Tschiesner U,Vahdati-Bolouri M,Segun Ismaila A,Suresh Punekar Y +8 more
TL;DR: A strong association exists between changes in spirometric measurements and changes in PROs in adults with chronic obstructive pulmonary disease.
References
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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
Journal ArticleDOI
The St George's Respiratory Questionnaire.
TL;DR: The St George's Respiratory Questionnaire is a standardized self-completed questionnaire for measuring impaired health and perceived well-being in airways disease and the background and rationale for its development are discussed together with an analysis of its performance.
Journal ArticleDOI
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
TL;DR: It is suggested that the frequency of exacerbations contributes to long term decline in lung function of patients with moderate to severe COPD.