Journal ArticleDOI
Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study
Marc Decramer,Kenneth R. Chapman,Ronald Dahl,Peter Frith,Gilles Devouassoux,Carlos Cezar Fritscher,Ray Cameron,Muhammad Shoaib,David Lawrence,David Young,Danny McBryan +10 more
TLDR
Indacaterol and tiotropium provided clinically relevant improvements in lung function with comparable safety profiles and the present data offer evidence consistent with current guidelines.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2013-09-01. It has received 230 citations till now. The article focuses on the topics: Tiotropium bromide & Indacaterol.read more
Citations
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Journal ArticleDOI
Informe 2017 de la Iniciativa Global para el Diagnóstico, Tratamiento y Prevención de la Enfermedad Pulmonar Obstructiva Crónica: Resumen Ejecutivo de GOLD
Claus Vogelmeier,Gerard J. Criner,Fernando J. Martinez,Antonio Anzueto,Peter J. Barnes,Jean Bourbeau,Bartolome R. Celli,Rongchang Chen,Marc Decramer,Leonardo M. Fabbri,Peter Frith,David M.G. Halpin,M. Victorina López Varela,Masaharu Nishimura,Nicolas Roche,Roberto Rodriguez-Roisin,Don D. Sin,Dave Singh,Robert A. Stockley,Jørgen Vestbo,Jadwiga A. Wedzicha,Alvar Agusti +21 more
TL;DR: Los cambios mas destacados incluyen: a) se ha diferenciado entre la exploracion espirometrica y the de los sintomas para evaluar la enfermedad pulmonar obstructiva cronica (EPOC) and b) se introduce el concepto de reduccion escalonada of the terapia en el esquema de evaluacion del tratamiento.
Journal ArticleDOI
Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials
Marc Decramer,Antonio Anzueto,Edward Kerwin,Thomas Kaelin,Nathalie Richard,Glenn Crater,Maggie Tabberer,Stephanie Harris,Alison Church +8 more
TL;DR: In both studies, the primary efficacy endpoint of both studies was trough forced expiratory volume in 1 s (FEV1) on day 169, which was analysed in the intention-to-treat population and noted improvements in trough FEV1 on day169 for both doses of UMEC plus VI compared with TIO monotherapy.
Journal ArticleDOI
An official American Thoracic Society/European Respiratory Society statement: research questions in COPD
Bartolome R. Celli,Marc Decramer,Jadwiga A. Wedzicha,Kevin C. Wilson,Alvar Agusti,Gerard J. Criner,William MacNee,Barry J. Make,Stephen I. Rennard,Robert A. Stockley,Claus Vogelmeier,Antonio Anzueto,David H. Au,Peter J. Barnes,Pierre-Régis Burgel,Peter M. Calverley,Ciro Casanova,Enrico Clini,Christopher B. Cooper,Harvey O. Coxson,Daniel Dusser,Leonardo M. Fabbri,Bonnie Fahy,Gary T. Ferguson,Andrew M. Fisher,Monica Fletcher,Maurice Hayot,John R. Hurst,Paul Jones,Donald A. Mahler,François Maltais,David M. Mannino,Fernando J. Martinez,Marc Miravitlles,Paula Meek,Alberto Papi,Klaus F. Rabe,Nicolas Roche,Frank C. Sciurba,Sanjay Sethi,Nikos M. Siafakas,Don D. Sin,Joan B. Soriano,James K. Stoller,Donald P. Tashkin,Thierry Troosters,Geert Verleden,Johny Verschakelen,Jørgen Vestbo,John W. Walsh,George R. Washko,Robert A. Wise,Emiel F.M. Wouters,Richard ZuWallack +53 more
TL;DR: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus, and the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes were highlighted.
Journal ArticleDOI
Impact and prevention of severe exacerbations of COPD: a review of the evidence.
TL;DR: Evidence-based approaches to prevent and manage severe exacerbations should be implemented as part of targeted strategies for disease management, and strategies to prevent readmission to hospital are identified.
Journal ArticleDOI
An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease
Bartolome R. Celli,Marc Decramer,Jadwiga A. Wedzicha,Kevin C. Wilson,Alvar Agustí,Gerard J. Criner,William MacNee,Barry Make,Stephen I. Rennard,Robert A. Stockley,Claus Vogelmeier,Antonio Anzueto,David H. Au,Peter J. Barnes,Pierre-Régis Burgel,Peter M.A. Calverley,Ciro Casanova,Enrico Clini,Christopher B. Cooper,Harvey O. Coxson,Daniel Dusser,Leonardo M. Fabbri,Bonnie Fahy,Gary T. Ferguson,Andrew M. Fisher,Monica Fletcher,Maurice Hayot,John R. Hurst,Paul Jones,Donald A. Mahler,François Maltais,David M. Mannino,Fernando J. Martinez,Marc Miravitlles,Paula Meek,Alberto Papi,Klaus F. Rabe,Nicolas Roche,Frank C. Sciurba,Sanjay Sethi,NM Siafakas,Don D. Sin,Joan B. Soriano,James K. Stoller,Donald P. Tashkin,Thierry Troosters,G.M. Verleden,Johny Verschakelen,Jørgen Vestbo,John W. Walsh,George R. Washko,Robert A. Wise,Emiel F.M. Wouters,Richard ZuWallack +53 more
TL;DR: This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.
References
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
Journal ArticleDOI
The St George's Respiratory Questionnaire.
TL;DR: The St George's Respiratory Questionnaire is a standardized self-completed questionnaire for measuring impaired health and perceived well-being in airways disease and the background and rationale for its development are discussed together with an analysis of its performance.
Journal ArticleDOI
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
TL;DR: It is suggested that the frequency of exacerbations contributes to long term decline in lung function of patients with moderate to severe COPD.