Journal ArticleDOI
Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study
Marc Decramer,Kenneth R. Chapman,Ronald Dahl,Peter Frith,Gilles Devouassoux,Carlos Cezar Fritscher,Ray Cameron,Muhammad Shoaib,David Lawrence,David Young,Danny McBryan +10 more
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TLDR
Indacaterol and tiotropium provided clinically relevant improvements in lung function with comparable safety profiles and the present data offer evidence consistent with current guidelines.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2013-09-01. It has received 230 citations till now. The article focuses on the topics: Tiotropium bromide & Indacaterol.read more
Citations
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An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease Executive Summary
Bartolome R. Celli,Marc Decramer,Jadwiga A. Wedzicha,Kevin C. Wilson,Alvar Agust,Gerard J. Criner,William MacNee,Barry Make,Stephen I. Rennard,Robert A. Stockley,Claus Vogelmeier,Antonio Anzueto,David H. Au,Peter J. Barnes,Pierre-Régis Burgel,Peter M.A. Calverley,Ciro Casanova,Enrico Clini,Christopher B. Cooper,Harvey O. Coxson,Daniel Dusser,Leonardo M. Fabbri,Bonnie Fahy,Gary T. Ferguson,Andrew J. Fisher,Monica Fletcher,Maurice Hayot,John R. Hurst,Paul Jones,Donald A. Mahler,François Maltais,David M. Mannino,Fernando J. Martinez,Marc Miravitlles,Paula Meek,Alberto Papi,Klaus F. Rabe,Nicolas Roche,Frank C. Sciurba,Sanjay Sethi,Nikos M. Siafakas,Don D. Sin,Joan B. Soriano,James K. Stoller,Donald P. Tashkin,Thierry Troosters,G.M. Verleden,Johny Verschakelen,Jørgen Vestbo,John W. Walsh,George R. Washko,Robert A. Wise,Emiel F.M. Wouters,Richard ZuWallack +53 more
TL;DR: The ATS/ERS Research Statement as discussed by the authors highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes, and provides recommendations for future research.
Journal ArticleDOI
Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial.
Peter M.A. Calverley,Antonio Anzueto,Kerstine Carter,Lars Grönke,Christoph Hallmann,Christine Jenkins,Jadwiga A. Wedzicha,Klaus F. Rabe +7 more
TL;DR: Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiottropium alone, and the proportion of patients reporting adverse events was similar between treatments.
Journal ArticleDOI
Blood Eosinophils and Response to Maintenance Chronic Obstructive Pulmonary Disease Treatment. Data from the FLAME Trial.
Nicolas Roche,Kenneth R. Chapman,Claus Vogelmeier,Felix J.F. Herth,Chau Thach,Robert Fogel,Petter Olsson,Francesco Patalano,Donald Banerji,Jadwiga A. Wedzicha +9 more
TL;DR: Prospective analyses indicate that indacaterol/glycopyrronium provides superior or similar benefits over salmeterol/fluticasone regardless of blood eosinophil levels in patients with COPD.
Journal ArticleDOI
An official American Thoracic Society/European Respiratory Society statement: research questions in COPD
Bartolome R. Celli,Marc Decramer,Jadwiga A. Wedzicha,Kevin C. Wilson,Alvar Agusti,Gerard J. Criner,William MacNee,Barry J. Make,Stephen I. Rennard,Robert A. Stockley,Claus Vogelmeier,Antonio Anzueto,David H. Au,Peter J. Barnes,Pierre-Régis Burgel,Peter M. Calverley,Ciro Casanova,Enrico Clini,Christopher B. Cooper,Harvey O. Coxson,Daniel Dusser,Leonardo M. Fabbri,Bonnie Fahy,Gary T. Ferguson,Andrew M. Fisher,Monica Fletcher,Maurice Hayot,John R. Hurst,Paul Jones,Donald A. Mahler,François Maltais,David M. Mannino,Fernando J. Martinez,Marc Miravitlles,Paula Meek,Alberto Papi,Klaus F. Rabe,Nicolas Roche,Frank C. Sciurba,Sanjay Sethi,Nikos M. Siafakas,Don D. Sin,Joan B. Soriano,James K. Stoller,Donald P. Tashkin,Thierry Troosters,Geert Verleden,Johny Verschakelen,Jørgen Vestbo,John W. Walsh,George R. Washko,Robert A. Wise,Emiel F.M. Wouters,Richard ZuWallack +53 more
TL;DR: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus, and highlighted the types of research that leading clinicians, researchers and patient advocates believe will have the greatest impact on patient-centred outcomes.
Journal ArticleDOI
LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis
Gustavo J Rodrigo,David Price,Antonio Anzueto,Dave Singh,Pablo Altman,Giovanni Bader,Francesco Patalano,Robert Fogel,Konstantinos Kostikas +8 more
TL;DR: The greater efficacy and comparable safety profiles observed withLABA/LAMA combinations versus LAMA or LABA/ICS support their potential role as first-line treatment options in COPD.
References
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
Journal ArticleDOI
The St George's Respiratory Questionnaire.
TL;DR: The St George's Respiratory Questionnaire is a standardized self-completed questionnaire for measuring impaired health and perceived well-being in airways disease and the background and rationale for its development are discussed together with an analysis of its performance.
Journal ArticleDOI
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
TL;DR: It is suggested that the frequency of exacerbations contributes to long term decline in lung function of patients with moderate to severe COPD.