One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
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TLDR
This protocol provides access to water-soluble dyes with large Stoke's shifts and far-red fluorescence emission that are envisioned as components of fluorescence-based sensors for a variety of imaging applications.About:
This article is published in Tetrahedron Letters.The article was published on 2007-06-18 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Xanthene.read more
Citations
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Fluorescent indicators for intracellular pH.
Junyan Han,Kevin Burgess +1 more
TL;DR: Various Indicators for Near-Neutral pH Values and Design of pH-Sensitive Cyanine Dyes and Miscellaneous Small Molecule pHi Indicators are presented.
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A Palette of Fluorescent Probes with Varying Emission Colors for Imaging Hydrogen Peroxide Signaling in Living Cells
TL;DR: When macrophages labeled with both PO1 and APF were stimulated to induce an immune response, they discovered three distinct types of phagosomes: those that generated mainly hROS, those that produced mainly H(2)O(2), and those that possessed both types of ROS.
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A Fluorescent Probe for the Detection of Myeloperoxidase Activity in Atherosclerosis-Associated Macrophages
Joanna Shepherd,Scott A. Hilderbrand,Peter Waterman,Jay W. Heinecke,Ralph Weissleder,Peter Libby +5 more
TL;DR: Fluorescence reflectance imaging by SNAPF may provide a valuable noninvasive molecular imaging tool for implicating HOCl and MPO in the damage of inflamed tissues.
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Applications of bismuth(III) compounds in organic synthesis
TL;DR: This review article summarizes the applications of bismuth(III) compounds in organic synthesis since 2002 and is largely organized by the reaction type although some reactions can be placed in multiple sections.
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7-Hydroxycoumarin−Hemicyanine Hybrids: A New Class of Far-Red Emitting Fluorogenic Dyes
TL;DR: The design and synthesis of novel water-soluble far-red emitting phenol-based fluorophores derived from 7-hydroxycoumarin are described and their utility was illustrated by the preparation of an original fluorogenic probe of penicillin G acylase whose fluorescence is unveiled through an enzyme-initiated domino reaction.
References
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Shedding light onto live molecular targets
TL;DR: Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances, which will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.
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Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species.
TL;DR: Not only can hROS be differentiated from hydrogen peroxide (H2O2), nitric oxide (NO), and superoxide (O 2 ⨪ ) by usingHPF or APF alone, but −OCl can also be specifically detected by using HPF and APF together.
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Cyanine dye labeling reagents: sulfoindocyanine succinimidyl esters
Ratnakar B. Mujumdar,Lauren A. Ernst,Swati R. Mujumdar,Christopher J. Lewis,Alan S. Waggoner +4 more
TL;DR: A series of new fluorescent labeling reagents based on sulfoindocyanine dyes contain succinimidyl ester reactive groups and can be readily conjugated to antibodies, avidin, DNA, lipids, polymers, and other amino-group-containing materials.
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Detection and Imaging of Zinc Secretion from Pancreatic β-Cells Using a New Fluorescent Zinc Indicator
TL;DR: Heterogeneity in secretion among cells was indicated in that some cells in a cluster did not release Zn2+.
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A Selective Fluorescent Sensor for Detecting Lead in Living Cells
TL;DR: Leadfluor-1 (LF1) is a new water-soluble, turn-on fluorescent sensor that is capable of selectively imaging Pb2+ in aqueous solution and in living cells, with sensitivity to parts per billion EPA limits for allowable lead in drinking water.
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