Outcomes of Kidney Transplantation in HIV-Infected Recipients
Peter G. Stock,Burc Barin,Barbara Murphy,Douglas W. Hanto,Jorge Diego,Jimmy A. Light,Charles E. L. B. Davis,Emily A. Blumberg,David Simon,Aruna Subramanian,J. Michael Millis,G. Marshall Lyon,Kenneth L. Brayman,Doug Slakey,Ron Shapiro,Joseph K. Melancon,Jeffrey M. Jacobson,Valentina Stosor,Jean L. Olson,Donald Stablein,Michelle E. Roland +20 more
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TLDR
In this cohort of carefully selected HIV-infected patients, both patient- and graft-survival rates were high at 1 and 3 years, with no increases in complications associated with HIV infection.Abstract:
Background The outcomes of kidney transplantation and immunosuppression in people infected with human immunodeficiency virus (HIV) are incompletely understood. Methods We undertook a prospective, nonrandomized trial of kidney transplantation in HIV-infected candidates who had CD4+ T-cell counts of at least 200 per cubic millimeter and undetectable plasma HIV type 1 (HIV-1) RNA levels while being treated with a stable antiretroviral regimen. Post-transplantation management was provided in accordance with study protocols that defined prophylaxis against opportunistic infection, indications for biopsy, and acceptable approaches to immunosuppression, management of rejection, and antiretroviral therapy. Results Between November 2003 and June 2009, a total of 150 patients underwent kidney transplantation; survivors were followed for a median period of 1.7 years. Patient survival rates (±SD) at 1 year and 3 years were 94.6±2.0% and 88.2±3.8%, respectively, and the corresponding mean graft-survival rates were 90....read more
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Infection in Organ Transplantation
TL;DR: Transplant infectious disease remains a key to the clinical and scientific investigation of organ transplantation and application of quantitative molecular microbial assays and advanced antimicrobial therapies have advanced care.
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KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis
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TL;DR: This commentary, developed by a panel of clinical experts convened by the National Kidney Foundation, attempts to put the KDIGO guideline for glomerulonephritis into the context of the US health care system and supports the vast majority of the recommendations.
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British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012
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TL;DR: These guidelines are aimed at clinical professionals directly involved with and responsible for the care of adults with HIV infection and at community advocates responsible for promoting the best interests and care of HIV-positive adults.
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Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America
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TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
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KDIGO Clinical Practice Guideline on the evaluation and management of candidates for kidney transplantation
Steven J. Chadban,Curie Ahn,David A. Axelrod,Bethany J. Foster,Bertram L. Kasiske,Vijah Kher,Deepali Kumar,Rainer Oberbauer,Julio Pascual,Helen Pilmore,James R. Rodrigue,Dorry L. Segev,Neil S. Sheerin,Kathryn Tinckam,Germaine Wong,Gregory A. Knoll +15 more
TL;DR: The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation.
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