Journal ArticleDOI
Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates
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TLDR
The data indicate that the rat nasal mucosa, which is the major target site for both aldehydes in inhalation toxicity studies, can metabolize both formaldehyde and acetaldehyde, and that the specific activities of formalde and aldehyde dehydrogenase in homogenates of the nasal mucoso are essentially unchanged following repeated exposures to toxic concentrations of either compound.About:
This article is published in Biochemical Pharmacology.The article was published on 1984-04-01. It has received 107 citations till now. The article focuses on the topics: Formaldehyde dehydrogenase & Acetaldehyde.read more
Citations
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Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment
TL;DR: Overall assessment of the cancer risk of aldehydes in the diet leads to the conclusion that formaldehyde, acrolein, citral and vanillin are no dietary risk factors, and that the opposite may be true for acetaldehyde, crotonaldehyde and furfural.
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Formaldehyde Toxicity—New Understanding
TL;DR: The sources, modes, and levels of exposure to human populations, reproductive, behavioral, and neurotoxic effects, dermal effects, and most of the earlier data pertaining to its genotoxicity are revealed.
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Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.
TL;DR: Treatment primarily requires restoration of normal sensory receptor growth, development and/or function and requires correction of steps initiating receptor and other pathology and includes zinc, theophylline, magnesium and fluoride.
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The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity.
TL;DR: Biological evidence suggests that there is no delivery of inhaled formaldehyde to distant sites, and that multiple inhalation bioassays have not induced leukemia in animals, and the negative findings provide convincing evidence that formaldehyde is not leukemogenic.
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Dose-dependent transitions in mechanisms of toxicity: case studies.
William Slikker,Melvin E. Andersen,Matthew S. Bogdanffy,James S. Bus,Steven D. Cohen,Rory B. Conolly,Raymond M. David,Nancy G. Doerrer,David C. Dorman,David W. Gaylor,Dale Hattis,John M. Rogers,R. Woodrow Setzer,James A. Swenberg,Kendall B. Wallace +14 more
TL;DR: A group of academic, government, and industry scientists, formed under the leadership of the ILSI Health and Environmental Sciences Institute (HESI), developed a series of case studies to illustrate the existence of dose-dependent transitions in mechanisms of toxicity.
References
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Journal ArticleDOI
A simplification of the protein assay method of Lowry et al. which is more generally applicable
TL;DR: A simple method based on a linear log-log protein standard curve is presented to permit rapid and totally objective protein analysis using small programmable calculators.
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Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Jozef Sedlak,Raymond H. Lindsay +1 more
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
Journal Article
Carcinogenicity of Formaldehyde in Rats and Mice after Long-Term Inhalation Exposure
TL;DR: Rhinitis, epithelial dysplasia, and squamous metaplasia occurred in all exposure groups of rats and in the intermediate and high exposure groups in mice, and formaldehyde inhalation was weakly associated with an increase in the frequency of polypoid adenomas in the nasal cavity of male rats.
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Bioavailability--a problem in equivalence.
TL;DR: Some statistical aspects of bioavailability are presented, which include the statistical considerations for designing and analyzing bioavailability studies, and various statistical approaches listed.