Journal ArticleDOI
Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish.
Ya-Li Wang,Wenwen Liu,Jing Yang,Fen Wang,Yizhen Sima,Zhaomin Zhong,Han Wang,Li-Fang Hu,Chun-Feng Liu +8 more
TLDR
It is reported that 4 weeks of rotenone treatment induced motor and non‐motor PD‐like symptoms in adult zebrafish, and these behavioral symptoms were associated with decreased levels of dopamine in the brains of rotonone‐treated fish.Abstract:
The pesticide rotenone is widely used to produce Parkinson’s disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior. Furthermore, rotenone-treated fish showed less of an olfactory preference for amino acid, indicating olfactory dysfunction. These behavioral symptoms were associated with decreased levels of dopamine in the brains of rotenone-treated fish. Taken together, these results suggest that rotenone-treated zebrafish are a suitable model of PD.read more
Citations
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Journal Article
MDS Clinical Diagnostic Criteria for Parkinson's Disease (S19.001)
Ronald B. Postuma,Daniela Berg +1 more
TL;DR: The International Parkinson and Movement Disorder Society (MDS) Clinical Diagnostic Criteria for Parkinson9s disease as discussed by the authors have been proposed for clinical diagnosis, which are intended for use in clinical research, but may also be used to guide clinical diagnosis.
Journal ArticleDOI
The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review.
TL;DR: Zebrafish have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire.
Journal ArticleDOI
Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.
TL;DR: Future technological developments alongside with a deeper understanding of the molecular bases of these disorders should enable the development of novel zebrafish lines that can prove useful for drug discovery for movement disorders.
Journal ArticleDOI
A novel approach to measure mitochondrial respiration in frozen biological samples
Rebeca Acín-Pérez,Ilan Y. Benador,Ilan Y. Benador,Anton Petcherski,Michaela Veliova,Gloria A. Benavides,Sylviane Lagarrigue,Arianne Caudal,Laurent Vergnes,Anne N. Murphy,Georgios Karamanlidis,Rong Tian,Karen Reue,Jonathan Wanagat,Harold S. Sacks,Francesca Amati,Victor M. Darley-Usmar,Marc Liesa,Ajit S. Divakaruni,Linsey Stiles,Orian S. Shirihai +20 more
TL;DR: A novel respirometry approach suited for frozen samples is described by restoring electron transfer components lost during freeze/thaw and correcting for variable permeabilization of mitochondrial membranes, finding that primary changes in mitochondrial function, detected in fresh tissue, are preserved in frozen samples years after collection.
References
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Journal ArticleDOI
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
TL;DR: It is reported that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity.
Journal ArticleDOI
MDS clinical diagnostic criteria for Parkinson's disease
Ronald B. Postuma,Daniela Berg,Matthew B. Stern,Werner Poewe,C. Warren Olanow,Wolfgang H. Oertel,Jose A. Obeso,Kenneth Marek,Irene Litvan,Anthony E. Lang,Glenda M. Halliday,Christopher G. Goetz,Thomas Gasser,Bruno Dubois,Piu Chan,Bastiaan R. Bloem,Charles H. Adler,Guenther Deuschl +17 more
TL;DR: The Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity, and two levels of certainty are delineated: clinically established PD and probable PD.
Journal Article
MDS Clinical Diagnostic Criteria for Parkinson's Disease (S19.001)
Ronald B. Postuma,Daniela Berg +1 more
TL;DR: The International Parkinson and Movement Disorder Society (MDS) Clinical Diagnostic Criteria for Parkinson9s disease as discussed by the authors have been proposed for clinical diagnosis, which are intended for use in clinical research, but may also be used to guide clinical diagnosis.
Journal ArticleDOI
Olfactory dysfunction in parkinsonism A general deficit unrelated to neurologic signs, disease stage, or disease duration
TL;DR: The data support the hypothesis that the olfactory deficit of PD is a general and stable one which likely occurs early in the disease process and is independent of all other measures, including disease stage and duration.
Journal ArticleDOI
Zebrafish as an emerging model for studying complex brain disorders.
TL;DR: It is argued that zebrafish models of complex brain disorders and drug-induced conditions are a rapidly emerging critical field in translational neuroscience and pharmacology research.
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