Parkinson’s disease with camptocormia
Frédéric Bloch,J. L. Houeto,S. Tezenas du Montcel,Fabrice Bonneville,Fabien Etchepare,M.-L. Welter,Sophie Rivaud-Péchoux,Valérie Hahn-Barma,Thierry Maisonobe,C. Béhar,J. Y. Lazennec,Ewa Kurys,Isabelle Arnulf,Anne-Marie Bonnet,Yves Agid +14 more
TLDR
Patients with camptocormia were characterised by prominent levodopa-unresponsive axial symptoms (ie, axial rigidity, gait disorder and postural instability), along with a tendency for greater error in the antisaccade paradigm, and it is suggested that the salient features of parkinsonism observed in patients with camps are likely to represent a specific form of Parkinson’s disease.Abstract:
Background: Camptocormia is defined as an abnormal flexion of the trunk that appears when standing or walking and disappears in the supine position. The origin of the disorder is unknown, but it is usually attributed either to a primary or a secondary paravertebral muscle myopathy or a motor neurone disorder. Camptocormia is also observed in a minority of patients with parkinsonism. Objective: To characterise the clinical and electrophysiological features of camptocormia and parkinsonian symptoms in patients with Parkinson’s disease and camptocormia compared with patients with Parkinson’s disease without camptocormia. Methods: Patients with parkinsonism and camptocormia (excluding patients with multiple system atrophy) prospectively underwent a multidisciplinary clinical (neurological, neuropsychological, psychological, rheumatological) and neurophysiological (electromyogram, ocular movement recording) examination and were compared with age-matched patients with Parkinson’s disease without camptocormia. Results: The camptocormia developed after 8.5 (SD 5.3) years of parkinsonism, responded poorly to levodopa treatment (20%) and displayed features consistent with axial dystonia. Patients with camptocormia were characterised by prominent levodopa-unresponsive axial symptoms (ie, axial rigidity, gait disorder and postural instability), along with a tendency for greater error in the antisaccade paradigm. Conclusion: We suggest that (1) the salient features of parkinsonism observed in patients with camptocormia are likely to represent a specific form of Parkinson’s disease and camptocormia is an axial dystonia and (2) both camptocormia and parkinsonism in these patients might result from additional, non-dopaminergic neuronal dysfunction in the basal ganglia.read more
Citations
More filters
Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Postural deformities in Parkinson's disease
Karen M. Doherty,Bart P.C. van de Warrenburg,Maria Cecilia Peralta,Laura Silveira-Moriyama,Jean-Philippe Azulay,Oscar S. Gershanik,Bastiaan R. Bloem +6 more
TL;DR: Improved understanding of the mechanisms underlying postural deformities in PD might ultimately lead to more effective management strategies for these disabling and drug-refractory complications.
Journal ArticleDOI
Measurement instruments to assess posture, gait, and balance in Parkinson's disease: Critique and recommendations
Bastiaan R. Bloem,Johan Marinus,Quincy J. Almeida,Lee Dibble,Alice Nieuwboer,Bart Post,Evzen Ruzicka,Christopher G. Goetz,Glenn T. Stebbins,Pablo Martinez-Martin,Anette Schrag +10 more
TL;DR: This MDS‐commissioned task force assessed clinimetric properties of existing rating scales, questionnaires, and timed tests that assess features in Parkinson's disease.
Journal ArticleDOI
Postural instability in patients with Parkinson's disease : epidemiology, pathophysiology and management
Samuel D. Kim,Samuel D. Kim,Natalie E. Allen,Colleen G. Canning,Victor S.C. Fung,Victor S.C. Fung +5 more
TL;DR: This paper showed that physical therapy, especially highly challenging balance exercises, can improve postural stability and reduce the risk of falls, although the long-term effects of physical therapy interventions on postural instability need to be explored given the progressive nature of PD.
Journal ArticleDOI
Postural disorders in Parkinson’s disease
TL;DR: Overall, postural impairment is poorly improved by levodopa, which implies that it is unlikely due to the nigrostriatal dopaminergic denervation, and the pedonculopontine nucleus seems promising as a new target for DBS in combination with the subthalamic nucleus.
References
More filters
Journal ArticleDOI
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
Jean-Jacques Hauw,S. E. Daniel,Dennis W. Dickson,D. S. Horoupian,Kurt A. Jellinger,Peter L. Lantos,Ann C. McKee,Massimo Tabaton,Irene Litvan +8 more
TL;DR: The preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) are presented as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.
Journal ArticleDOI
The antisaccade: a review of basic research and clinical studies
Stefan Everling,Burkhart Fischer +1 more
TL;DR: What is currently known about the neural structures and processes which are involved in the performance of this task is reviewed and the potential of the antisaccade task for diagnostic purposes is evaluated.
Journal ArticleDOI
Effect of GPi pallidotomy on motor function in Parkinson's disease
Andres M. Lozano,Anthony E. Lang,Nestor Galvez-Jimenez,Janis M. Miyasaki,J Duff,William D. Hutchison,Jonathan O. Dostrovsky +6 more
TL;DR: In these patients GPi pallidotomy enhanced motor performance, reduced akinesia, improved gait, and eliminated the neural elements responsible for levodopa-induced dyskinesias.
Journal ArticleDOI
Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy
TL;DR: It is reported that the hindbrain NPP Ch5 cell group, thought to innervate many nuclei of the extrapyramidal motor system, the superior colliculus, and the substantia innominata, undergoes degeneration in idiopathic Parkinson disease and in the parkinsonian syndrome of progressive supranuclear palsy.
Related Papers (5)
Camptocormia: Pathogenesis, classification, and response to therapy
Shaheda N. Azher,Joseph Jankovic +1 more