Parkinson’s disease with camptocormia
Frédéric Bloch,J. L. Houeto,S. Tezenas du Montcel,Fabrice Bonneville,Fabien Etchepare,M.-L. Welter,Sophie Rivaud-Péchoux,Valérie Hahn-Barma,Thierry Maisonobe,C. Béhar,J. Y. Lazennec,Ewa Kurys,Isabelle Arnulf,Anne-Marie Bonnet,Yves Agid +14 more
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TLDR
Patients with camptocormia were characterised by prominent levodopa-unresponsive axial symptoms (ie, axial rigidity, gait disorder and postural instability), along with a tendency for greater error in the antisaccade paradigm, and it is suggested that the salient features of parkinsonism observed in patients with camps are likely to represent a specific form of Parkinson’s disease.Abstract:
Background: Camptocormia is defined as an abnormal flexion of the trunk that appears when standing or walking and disappears in the supine position. The origin of the disorder is unknown, but it is usually attributed either to a primary or a secondary paravertebral muscle myopathy or a motor neurone disorder. Camptocormia is also observed in a minority of patients with parkinsonism. Objective: To characterise the clinical and electrophysiological features of camptocormia and parkinsonian symptoms in patients with Parkinson’s disease and camptocormia compared with patients with Parkinson’s disease without camptocormia. Methods: Patients with parkinsonism and camptocormia (excluding patients with multiple system atrophy) prospectively underwent a multidisciplinary clinical (neurological, neuropsychological, psychological, rheumatological) and neurophysiological (electromyogram, ocular movement recording) examination and were compared with age-matched patients with Parkinson’s disease without camptocormia. Results: The camptocormia developed after 8.5 (SD 5.3) years of parkinsonism, responded poorly to levodopa treatment (20%) and displayed features consistent with axial dystonia. Patients with camptocormia were characterised by prominent levodopa-unresponsive axial symptoms (ie, axial rigidity, gait disorder and postural instability), along with a tendency for greater error in the antisaccade paradigm. Conclusion: We suggest that (1) the salient features of parkinsonism observed in patients with camptocormia are likely to represent a specific form of Parkinson’s disease and camptocormia is an axial dystonia and (2) both camptocormia and parkinsonism in these patients might result from additional, non-dopaminergic neuronal dysfunction in the basal ganglia.read more
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Neuroproteomics as a promising tool in Parkinson's disease research.
TL;DR: It is hoped that the application of neuroproteomics will lead towards a presymptomatic diagnosis of PD, and the identification of risk factors and new therapeutic targets at which pharmacological intervention can be aimed.
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Diagnostic criteria for camptocormia in Parkinson's disease: A consensus-based proposal
Alfonso Fasano,Christian Geroin,Alfredo Berardelli,Bastiaan R. Bloem,Alberto J. Espay,Mark Hallett,Anthony E. Lang,Michele Tinazzi +7 more
TL;DR: The ascertainment of upper and lower camptocormia subtypes could improve the validity of epidemiological studies and assist future therapeutic trials.
Journal ArticleDOI
Clinical Definition of Camptocormia in Parkinson's Disease
Nils G. Margraf,Oliver Granert,Julia Hampel,Arne Wrede,Walter J. Schulz-Schaeffer,Günther Deuschl +5 more
TL;DR: Clinical key aspects of camptocormia in patients with idiopathic Parkinson's disease (PD) await further definition.
Journal ArticleDOI
Therapy-resistant symptoms in Parkinson’s disease
TL;DR: This work will focus on freezing of gait, camptocormia, dysphagia and dysphonia, as well as cognitive impairment and dementia because they represent the far end of therapy-resistant symptoms, encompassing poor health-related quality of life and often a more reserved prognosis with either a rapid evolution of the disease, and/or merely a more severe clinical picture.
Journal ArticleDOI
Postural Abnormalities in Parkinson's Disease: An Epidemiological and Clinical Multicenter Study
Michele Tinazzi,Marialuisa Gandolfi,Roberto Ceravolo,Marianna Capecci,Elisa Andrenelli,Maria Gabriella Ceravolo,Laura Bonanni,Marco Onofrj,Michela Vitale,Mauro Catalan,Paola Polverino,Claudio Bertolotti,Sonia Mazzucchi,Sara Giannoni,Nicola Smania,Stefano Tamburin,Laura Vacca,Fabrizio Stocchi,Fabiana Giada Radicati,Carlo Alberto Artusi,Maurizio Zibetti,Leonardo Lopiano,Alfonso Fasano,Alfonso Fasano,Christian Geroin +24 more
TL;DR: The overall frequency of postural abnormalities in Parkinson's disease is unknown and the association with demographic and clinical variables is assessed.
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