Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
Reads0
Chats0
TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
More filters
Journal ArticleDOI
Sequentially targeting and intervening mutual Polo-like Kinase 1 on CAFs and tumor cells by dual targeting nano-platform for cholangiocarcinoma treatment
Yue Zhou,Lei Xu,Zhan-huai Wang,Hongwen Liu,Xiang Zhang,Chuanjun Shu,Meng Zhang,Ting Wang,Xinyun Xu,XiaoHong Pu,Jian He,Pinghan Wang,Yudong Qiu,Guifang Xu,Xiaoping Zou,Yu Jie Zhu,Lei Wang +16 more
TL;DR:
Journal ArticleDOI
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice
Ming Zhao,Yingyao Quan,Yingyao Quan,Jianming Zeng,Xueying Lyu,Haitao Wang,Josh Haipeng Lei,Yangyang Feng,Jun Xu,Qiang Chen,Heng Sun,Xiaoling Xu,Ligong Lu,Chu-Xia Deng +13 more
TL;DR: In this paper, a genome-wide CRISPR-Cas9 screening was conducted in liver-specific Smad4/Pten knockout mice and 15 putative tumor suppressor genes, including Cullin3 (Cul3), whose deficiency increases protein levels of Nrf2 and Cyclin D1 leading to the initiation of cholangiocytes.
Journal ArticleDOI
Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models
Hiroyuki Tomita,Akira Hara +1 more
TL;DR: In this article , a review of the pathogenesis and mechanisms of eCCA that can be revealed by genetically engineered mouse models (GEMMs) is presented. But the authors do not discuss several clinical questions, such as whether BilIN and IPNB really become malignant, whether the peribiliary gland is the origin of ECCAs, and others.
Journal ArticleDOI
Dynamic enhancement patterns of small-diameter mass-forming intrahepatic cholangiocarcinomas on contrast-enhanced magnetic resonance imaging: Challenges faced by the radiologist.
TL;DR: The small-diameter mass-forming ICC nodules mainly show peripheral continuous enhancement on contrast-enhanced MRI; however, those with diameters <2 cm commonly show progressive enhancement.
Dissertation
Biliary epithelial cells, the immune system and PSC pathogenesis
TL;DR: Cellular and humoral components of the immune system, in PSC and the PSC-associated malignancy CCA and immunohistochemistry assessment of intratumoral immune cells in cholangiocarcinoma are investigated.
References
More filters
Journal ArticleDOI
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
TL;DR: Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer and was associated with a significant survival advantage without the addition of substantial toxicity.
Journal ArticleDOI
Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
Journal ArticleDOI
The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.