Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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Recent advances of immunotherapy for biliary tract cancer.
TL;DR: The durable responses observed in sporadic cases suggest that testing patients for MMR, MSI, TMB, and PD-L1 expression is warranted, and a report of ongoing Phase I to III clinical trials assessing ICIs and new immunotherapeutic strategies for advanced BTC is provided.
Journal ArticleDOI
Hepatolithiasis and intrahepatic cholangiocarcinoma: A review
Hyo Jung Kim,Jae Seon Kim,Moon Kyung Joo,Beom Jae Lee,Ji Hoon Kim,Jong Eun Yeon,Jong Jae Park,Kwan Soo Byun,Young Tae Bak +8 more
TL;DR: Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliary-enteric anastomosis, and it is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA.
Journal ArticleDOI
Profiles of Cancer Stem Cell Subpopulations in Cholangiocarcinomas
Vincenzo Cardinale,Anastasia Renzi,Guido Carpino,A. Torrice,Maria Consiglia Bragazzi,Felice Giuliante,Agostino M. Derose,A. Fraveto,Paolo Onori,Chiara Napoletano,Antonio Franchitto,Alfredo Cantafora,Gian Luca Grazi,Nicola Caporaso,Giuseppe D'Argenio,Gianfranco Alpini,Lola M. Reid,Eugenio Gaudio,Domenico Alvaro +18 more
TL;DR: CSCs were rich in human CCAs, implicating CCAs as stem cell-based diseases, and reproducing the original humanCCAs when injected into cirrhotic livers is remarkable.
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Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma.
Zhuo-Xian Rong,Zhi Li,Jun-Ju He,Liyu Liu,Xinxin Ren,Jie Gao,Yun Mu,Yi-Di Guan,Yumei Duan,Xiu-Ping Zhang,De-Xiang Zhang,Nan Li,Yuezhen Deng,Lun-Quan Sun +13 more
TL;DR: It is shown here that the protein level of FTO was downregulated in clinical ICC samples and cell lines and that FTO expression was inversely correlated with the expression of CA19-9 and micro-vessel density (MVD).
References
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
TL;DR: Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer and was associated with a significant survival advantage without the addition of substantial toxicity.
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.