Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
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PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect
Dan Li,Chaoqun Wang,Panfei Ma,QingAn Yu,Mingqi Gu,Liqian Dong,Wenjing Jiang,Shangha Pan,Changming Xie,Jihua Han,Yaliang Lan,Jing Sun,Ping Sheng,Kunpeng Liu,Yaohua Wu,Lianxin Liu,Yong Ma,Hongchi Jiang +17 more
TL;DR: The study suggests the potential utility of developing the P GC1α-targeted therapies or blocking PGC1α signaling axis for inhibiting CCA metastasis and illuminated that PGC 1α reversed the Warburg effect by upregulating the expression of pyruvate dehydrogenase E1 alpha 1 subunit.
Journal ArticleDOI
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells
Xiwei Ding,Xiwei Ding,Roongruedee Chaiteerakij,Roongruedee Chaiteerakij,Catherine D. Moser,Hassan M. Shaleh,Jeffrey Boakye,Gang Chen,Albert Ndzengue,Ying Li,Yanling Zhou,Shengbing Huang,Frank A. Sinicrope,Xiaoping Zou,Melanie B. Thomas,Charles D. Smith,Lewis R. Roberts +16 more
TL;DR: Findings provide novel evidence that Sphk2 may be a rational therapeutic target in cholangiocarcinoma and Combinations of ABC294640 with sorafenib and/or autophagy inhibitors may provide novel strategies for the treatment of cholangsiocARCinoma.
Journal ArticleDOI
Upregulated long noncoding RNA PANDAR predicts an unfavorable prognosis and promotes tumorigenesis in cholangiocarcinoma.
Yi Xu,Xingming Jiang,Yunfu Cui +2 more
TL;DR: The findings showed that lncRNA PANDAR serves as a novel prognostic biomarker and therapeutic target for CCA.
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Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis
Sumera Rizvi,Joachim C. Mertens,Steven F. Bronk,Petra Hirsova,Haiming Dai,Lewis R. Roberts,Scott H. Kaufmann,Gregory J. Gores +7 more
TL;DR: Findings indicate that apoptotic priming of CAF by PDGF occurs via Puma-mediated Bak activation, which can be converted to active full-blown apoptosis by navitoclax or ABT-199 for therapeutic benefit.
Journal ArticleDOI
Circulating Tumor DNA Profiling of Advanced Biliary Tract Cancers
Kabir Mody,Pashtoon Murtaza Kasi,Ju Dong Yang,Phani Keerthi Surapaneni,Tanios Bekaii-Saab,Daniel H. Ahn,Amit Mahipal,Mohamad Bassam Sonbol,Jason S. Starr,Ali Roberts,Rebecca Nagy,Richard B. Lanman,Mitesh J. Borad +12 more
TL;DR: This study, the largest cohort reported to date to the authors' knowledge, demonstrates the feasibility of ctDNA testing in biliary tract cancers, and provides a foundation upon which the field can continue to grow.
References
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Fibroblasts in cancer
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Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.