Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
TL;DR: The data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr- 1 in cholangiocarcinoma carcinogenesis.
Journal ArticleDOI
Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation
Hiroaki Fujiwara,Keisuke Tateishi,Kento Misumi,Akimasa Hayashi,Kaori Igarashi,Hiroyuki S. Kato,Takuma Nakatsuka,Nobumi Suzuki,Keisuke Yamamoto,Yotaro Kudo,Yoku Hayakawa,Hayato Nakagawa,Yasuo Tanaka,Hideaki Ijichi,Hirofumi Kogure,Y. Nakai,Hiroyuki Isayama,Kiyoshi Hasegawa,Masashi Fukayama,Tomoyoshi Soga,Kazuhiko Koike +20 more
TL;DR: It is demonstrated that mutant IDH1 increased the formation of IBOs as well as accelerated glucose metabolism and survived the suppression of ATP production caused by growth factor depletion and matrix detachment by retaining high ATP levels through 5ʹ adenosine monophosphate-activated protein kinase (AMPK) activation.
Journal ArticleDOI
Targeting lymphangiogenesis and lymph node metastasis in liver cancer
Sukanya Roy,Priyanka Banerjee,Burcin Ekser,Kayla J. Bayless,David C. Zawieja,Gianfranco Alpini,Gianfranco Alpini,Shannon Glaser,Sanjukta Chakraborty +8 more
TL;DR: In this article, a detailed perspective on the current knowledge of alterations in the hepatic lymphatic system during liver malignancies, as well as various molecular signaling mechanisms and growth factors that may provide future targets for therapeutic intervention is provided.
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MicroRNA-31 reflects IL-6 expression in cancer tissue and is related with poor prognosis in bile duct cancer.
Keisuke Ishigami,Katsuhiko Nosho,Hideyuki Koide,Shinichi Kanno,Kei Mitsuhashi,Hisayoshi Igarashi,Masahiro Shitani,Masayo Motoya,Yasutoshi Kimura,Tadashi Hasegawa,Hiroyuki Kaneto,Ichiro Takemasa,Hiromu Suzuki,Hiroshi Nakase +13 more
TL;DR: The findings suggest that miR-31 may be a promising biomarker that reflects IL-6 expression in bile duct cancer tissues and predicts poor prognosis.
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A review of systemic therapy in biliary tract carcinoma
TL;DR: An unmet need exists not only to develop new and more effective therapies for this devastating disease, but also to integrate original research findings into a more complex, dynamic, individualized therapeutic decision model to aid clinicians in making evidence-based, best therapeutic decisions for individual patients.
References
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
TL;DR: Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer and was associated with a significant survival advantage without the addition of substantial toxicity.
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.