Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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Chronic inflammation and cytokines in the tumor microenvironment.
TL;DR: The role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis are explored.
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Cholangiocarcinoma — evolving concepts and therapeutic strategies
TL;DR: Advances in comprehensive whole-exome and transcriptome sequencing have defined the genetic landscape of each cholangiocarcinoma subtype, and promising molecular targets for precision medicine have been identified, and are being evaluated in clinical trials, including those exploring immunotherapy.
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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Jesus M. Banales,Vincenzo Cardinale,Guido Carpino,Marco Marzioni,Jesper B. Andersen,Pietro Invernizzi,Guro Elisabeth Lind,Trine Folseraas,Stuart J. Forbes,Laura Fouassier,Andreas Geier,Diego F. Calvisi,Joachim C. Mertens,Michael Trauner,Antonio Benedetti,Luca Maroni,Javier Vaquero,Rocio I.R. Macias,Chiara Raggi,Maria J. Perugorria,Eugenio Gaudio,Kirsten Muri Boberg,Jose J.G. Marin,Domenico Alvaro +23 more
TL;DR: This Consensus Statement aims to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer.
Journal ArticleDOI
Genomic spectra of biliary tract cancer
Hiromi Nakamura,Yasuhito Arai,Yasushi Totoki,Tomoki Shirota,Asmaa Elzawahry,Mamoru Kato,Natsuko Hama,Fumie Hosoda,Tomoko Urushidate,Shoko Ohashi,Nobuyoshi Hiraoka,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Tomoo Kosuge,Shinichi Miyagawa,Tatsuhiro Shibata +16 more
TL;DR: The subgroup with the poorest prognosis had significant enrichment of hypermutated tumors and a characteristic elevation in the expression of immune checkpoint molecules, suggesting immune-modulating therapies might also be potentially promising options for these patients.
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Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study
Ghassan K. Abou-Alfa,Ghassan K. Abou-Alfa,Vaibhav Sahai,Antoine Hollebecque,Gina M. Vaccaro,Davide Melisi,Raed Al-Rajabi,Andrew Scott Paulson,Mitesh J. Borad,David Gallinson,Adrian Murphy,Do Youn Oh,Efrat Dotan,Daniel V.T. Catenacci,Eric Van Cutsem,Tao Ji,Christine F. Lihou,Hui-Ling Zhen,Luis Féliz,Arndt Vogel +19 more
TL;DR: These data support the therapeutic potential of pemigatinib in previously treated patients with cholangiocarcinoma who have FGFR2 fusions or rearrangements.
References
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Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.
Patrick Baril,Rathi Gangeswaran,Patrick C. Mahon,K Caulee,Hemant M. Kocher,Tomohiko Harada,M Zhu,Holger Kalthoff,Tatjana Crnogorac-Jurcevic,Nicholas R. Lemoine +9 more
TL;DR: It is demonstrated that periostin promotes the invasiveness of tumour cells by increasing the motility of cells without inducing expression of proteases, and enhances the survival of tumours exposed to hypoxic conditions.
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Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
Sayaka Sekiya,Atsushi Suzuki +1 more
TL;DR: The studies reveal that ICC is generated by biliary lineage cells derived from hepatocytes, rather than cholangiocytes, and found that Notch activation is critical for hepatocyte conversion into biliary dynasty cells during the onset of ICC and its subsequent malignancy and progression.
Journal ArticleDOI
Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes
Mina Komuta,Olivier Govaere,Vincent Vandecaveye,Jun Akiba,Werner Van Steenbergen,Chris Verslype,Wim Laleman,Jacques Pirenne,Raymond Aerts,Hirohisa Yano,Frederik Nevens,Baki Topal,Tania Roskams +12 more
TL;DR: Muc‐ICCs had a clinicopathological, immunohistochemical, and molecular profile similar to that of hilar CCs (from mucin‐producing cholangiocytes), whereas mixed‐ICC had a profile similarto that of CLCs (thought to be of HPC origin), possibly reflecting their respective cells of origin.
Journal ArticleDOI
Oxysterols are allosteric activators of the oncoprotein Smoothened
Sigrid Nachtergaele,Laurel K Mydock,Kathiresan Krishnan,Jayan Rammohan,Paul H. Schlesinger,Douglas F. Covey,Rajat Rohatgi +6 more
TL;DR: This work synthesized the enantiomer and an epimer of the most potent oxysterol, 20(S)-hydroxycholesterol, and shows that the effects of oxysterols on Hedgehog signaling are exquisitely stereoselective, consistent with their function through a specific protein target.
Journal ArticleDOI
New staging system and a registry for perihilar cholangiocarcinoma
Michelle L. DeOliveira,Richard D. Schulick,Yuji Nimura,Charles B. Rosen,Gregory J. Gores,Peter Neuhaus,Pierre-Alain Clavien +6 more
TL;DR: A new system reporting the size of the tumor, the extent of the disease in the biliary system, the involvement of the hepatic artery and portal vein, the involved of lymph nodes, distant metastases, and the volume of the putative remnant liver after resection is designed.