Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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Posted ContentDOI
Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma
Aleksandar Obradovic,Lorenzo Tomassoni,Daoqi Yu,Kristina Guillan,Katie Souto,E. Fraser,Susan Bates,Charles G. Drake,Yvonne M. Saenger,Filemon S. Dela Cruz,Andrew C. Kung,Andrea Califano +11 more
TL;DR: A highly generalizable, single-cell framework for the mechanism-based prioritization of drugs to treat rare, highly heterogeneous tumors is introduced and can be generalized to elucidate complementary dependencies of rare, heterogeneity tumors, at the single cell level.
Journal ArticleDOI
Development of a genomic predictive model for cholangiocarcinoma using copy number alteration data.
Inês Tavares,Ricardo Martins,Ilda Patrícia Ribeiro,Luísa Esteves,Francisco Caramelo,Ana M. Abrantes,Rita Neves,Rui Caetano-Oliveira,Maria Filomena Botelho,Joana B. Melo,Dulce Diogo,José Guilherme Tralhão,Isabel M. Carreira +12 more
TL;DR: In this paper, the authors performed a genomic characterisation of cholangiocarcinoma (CC) tumours and implemented a model to differentiate extrahepatic (ECC) and intrahempatic (ICC) CHolangio-carcinoma, and performed a survival analysis comparing both groups of patients.
Journal ArticleDOI
Hepatic intra-arterial and systemic chemotherapy followed by maintenance therapy for the treatment of cholangiocarcinoma.
Giammaria Fiorentini,Andrea Mambrini,Donatella Sarti,Maurizio Cantore,Luca Mulazzani,Gian Maria Mattioli,Stefano Guadagni +6 more
TL;DR: Cholangiocarcinoma patients may benefit from IAHCT-SCHT, and gemcitabine-based maintenance therapy (maintenance) may prolong clinical benefits.
Book ChapterDOI
Intrahepatic and Hilar Cholangiocarcinomas: Epidemiology, Basic Principles of Treatment, and Clinical Data
TL;DR: This chapter reviews the epidemiology, risk factors, and pathogenesis of intrahepatic and hilar cholangiocarcinomas, as well as the basic principles of diagnosis, staging, and treatment.
References
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
Journal ArticleDOI
The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.