Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.
Richard D. Kim,Hanna K. Sanoff,Andrew Poklepovic,Heloisa P. Soares,Jongphil Kim,Jing Lyu,Yingmiao Liu,Andrew B. Nixon,Dae-Won Kim +8 more
TL;DR: This study evaluated the efficacy of regorafenib in refractory biliary tract cancer in a multi‐institutional phase 2 study.
Journal ArticleDOI
Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: Review of the literature.
Fabio Frosio,Federico Mocchegiani,Grazia Conte,Enrico Dalla Bona,A. Vecchi,Daniele Nicolini,Marco Vivarelli +6 more
TL;DR: The current role of neoadjuvant RCT before resection as well as before OLT is analyzed, with results indicating that for patients meeting the Mayo Clinic criteria, RCT prior to orthotopic liver transplant (OLT) has proved to produce acceptable 5-years survivals.
Journal ArticleDOI
Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
TL;DR: CDR1as might exert oncogenic properties, at least partially, by regulating miR-641 in CCA, and could be considered therapeutic targets for CCA.
Journal ArticleDOI
LncRNA NR-104098 Inhibits AML Proliferation and Induces Differentiation Through Repressing EZH2 Transcription by Interacting With E2F1
Yubin Feng,Yubin Feng,Shuang Hu,Shuang Hu,Lanlan Li,Lanlan Li,Shengpeng Zhang,Jikang Liu,Jikang Liu,Xiaoling Xu,Xiaoling Xu,Meiju Zhang,Meiju Zhang,Tianxi Du,Tianxi Du,Yan Du,Yan Du,Xiaoqing Peng,Xiaoqing Peng,Feihu Chen,Feihu Chen +20 more
TL;DR: It is identified that lncRNA NR-104098 is a suppressor gene that is significantly upregulated in AML cells and its specific mechanism is investigated, leading to deeper insight into the mechanism of ATPR-induced AML differentiation and prevent proliferation by inhibiting EZH2 on the transcriptional level.
Journal ArticleDOI
Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo.
Huaqiang Zhu,Jin-Ben Ma,Xie Song,Hengjun Gao,Chaoqun Ma,Hong Chang,Hongguang Li,Fangfeng Liu,Jun Lu,Xu Zhou +9 more
TL;DR: The results presented here indicate that metformin may be a potent agent for enhancing the efficacy of gemcitabine and cisplatin in the treatment of cholangiocarcinoma.
References
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.