Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Sumera Rizvi,Gregory J. Gores +1 more
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TLDR
A better understanding of the imaging characteristics of iCCAs is gained and advanced cytologic techniques to detect pCCAs are developed, along with advances in classification, diagnosis, and treatment.About:
This article is published in Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 930 citations till now.read more
Citations
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Preoperative staging of cholangiocarcinoma and biliary carcinoma using 18F-fluorodeoxyglucose positron emission tomography: A meta-analysis
TL;DR: 18F-FDG-PET and PET/CT were found to be accurate in the evaluation of primary tumors, lymph node metastasis, and distant metastasis in patients with CCA.
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Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.
Massimiliano Cadamuro,Simone Brivio,Carlo Spirli,Ruth E. Joplin,Mario Strazzabosco,Mario Strazzabosco,Luca Fabris +6 more
TL;DR: It is concluded that improved understanding of the complex interplay between apoptosis signaling and the promotion of cell survival represent potentially productive areas for active investigation, with the ultimate aim of encouraging future studies to unveil new, effective strategies able to overcome current limitations on treatment.
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Histone deacetylase 3 overexpression in human cholangiocarcinoma and promotion of cell growth via apoptosis inhibition.
Yuyao Yin,Mingming Zhang,Robert G. Dorfman,Yang Li,Zhenguo Zhao,Yida Pan,Qian Zhou,Shan Huang,Shimin Zhao,Yuling Yao,Xiaoping Zou +10 more
TL;DR: It is demonstrated for the first time that MI192 targets HDAC3 and induces apoptosis in human CCA cells, and shows the potential as a new drug candidate for CCA therapy.
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Application of Immunohistochemistry in Gastrointestinal and Liver Neoplasms: New Markers and Evolving Practice
Zongming Eric Chen,Fan Lin +1 more
TL;DR: Assessment of predictive and prognostic markers by immunohistochemistry in routine pathologic diagnosis is a new trend and will greatly facilitate the advancement of personalized cancer therapy.
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The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma.
Tao Peng,Xiang Deng,Feng Tian,Zhonghu Li,Peng Jiang,Xin Zhao,Guangyu Chen,Yan Chen,Ping Zheng,Dajiang Li,Shuguang Wang +10 more
TL;DR: The GATA6/LOXL2 complex represents a novel candidate prognostic marker for stratifying patients with CCA and drugs targeting this complex may possess great therapeutic value in the treatment of CCA.
References
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Journal ArticleDOI
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
Juan Ignacio Valle,Harpreet Wasan,Daniel H. Palmer,David Cunningham,Alan Anthoney,Anthony Maraveyas,Srinivasan Madhusudan,Timothy Iveson,Sharon M. Hughes,Stephen P. Pereira,M Roughton,John Bridgewater +11 more
TL;DR: Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer and was associated with a significant survival advantage without the addition of substantial toxicity.
Journal ArticleDOI
Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.