Journal ArticleDOI
Pathology of hepatic iron overload.
Yves Deugnier,Bruno Turlin +1 more
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TLDR
The growing availability of genetic tests for most inherited iron-overload conditions and the current ability to assess hepatic iron stores, and at a lesser extent, liver fibrosis by noninvasive methods have reduced the need for liver biopsy in patients with hepaticiron excess.Abstract:
The growing availability of genetic tests for most inherited iron-overload conditions and our current ability to assess hepatic iron stores, and at a lesser extent, liver fibrosis by noninvasive methods have reduced the need for liver biopsy in patients with hepatic iron excess. Histologic evaluation of the liver remains useful (1) in well-defined genetic iron overload disorders to evaluate associated hepatic damage, (2) in unclassified genetic or acquired iron excess to guide etiologic diagnosis and to establish prognosis, and (3) in research studies for a whole and reliable assessment of the liver. The identification of iron overload, the description of its cellular and lobular distribution, semiquantitative assessment of its amount, and inventory of associated lesions, especially fibrosis, are the pathologist's main objectives.read more
Citations
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Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)
TL;DR: The third edition of the TIF guidelines was published by Musallam et al. as mentioned in this paper and includes updated information on new approaches for more effective, safe and less laborious treatment, and an overview of the progress achieved to date towards a total cure using methods such as gene therapy and stem cell transplantation.
Journal ArticleDOI
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib.
Christophe Louandre,Zakaria Ezzoukhry,Corinne Godin,Jean-Claude Barbare,Jean-Claude Mazière,Bruno Chauffert,Antoine Galmiche +6 more
TL;DR: The depletion of the intracellular iron stores achieved by using the iron chelator deferoxamine (DFX) strikingly protects HCC cells from the cytotoxic effects of sorafenib, identifying ferroptosis as an effective mechanism for the induction of cell death in HCC.
Journal ArticleDOI
Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
James E. Nelson,Laura A. Wilson,Elizabeth M. Brunt,Matthew M. Yeh,David E. Kleiner,Aynur Unalp-Arida,Kris V. Kowdley +6 more
TL;DR: The presence and pattern of hepatic iron deposition are associated with distinct histological features in patients with NAFLD and may have implications for pathophysiology and therapy.
Journal ArticleDOI
An overview of molecular basis of iron metabolism regulation and the associated pathologies
Bruno Silva,Paula Faustino +1 more
TL;DR: Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
Journal ArticleDOI
Clinical Quantitative Susceptibility Mapping (QSM): Biometal Imaging and Its Emerging Roles in Patient Care
Yi Wang,Yi Wang,Pascal Spincemaille,Zhe Liu,Zhe Liu,Alexey Dimov,Alexey Dimov,Kofi Deh,Jianqi Li,Yan Zhang,Yihao Yao,Yihao Yao,Kelly M. Gillen,Alan H. Wilman,Ajay Gupta,Apostolos John Tsiouris,Ilhami Kovanlikaya,Gloria C. Chiang,Jonathan W. Weinsaft,Lawrence Tanenbaum,Weiwei Chen,Wenzhen Zhu,Shixin Chang,Min Lou,Brian H. Kopell,Michael G. Kaplitt,David Devos,Toshinori Hirai,Xuemei Huang,Yukunori Korogi,Alexander Shtilbans,Alexander Shtilbans,Geon Ho Jahng,Daniel Pelletier,Susan A. Gauthier,David Pitt,Ashley I. Bush,Gary M. Brittenham,Martin R. Prince +38 more
TL;DR: This review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care.
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