Journal ArticleDOI
Pd-Catalyzed Regio- and Stereoselective C-Nucleoside Synthesis from Unactivated Uracils and Pyranoid Glycals
Faheem Rasool,Debaraj Mukherjee +1 more
TLDR
Pd-catalyzed regio- and stereoselective C-nucleoside synthesis from pyranoid glycals and unactivated N,N-dialkyluracils is described, which obviates the use of heavy metals such as mercury or preactivation of protected uracils, making it an attractive strategy for C- nucleosides synthesis.About:
This article is published in Organic Letters.The article was published on 2017-09-06. It has received 11 citations till now. The article focuses on the topics: Glycal.read more
Citations
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Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schraga Schwartz,Douglas A. Bernstein,Maxwell R. Mumbach,Marko Jovanovic,Rebecca H. Herbst,Brian X. León-Ricardo,Jesse M. Engreitz,Mitchell Guttman,Rahul Satija,Eric S. Lander,Gerald R. Fink,Aviv Regev,Aviv Regev,Aviv Regev +13 more
TL;DR: This work identifies an enhanced, transcriptome-wide scope for pseudouridine and methods to dissect its underlying mechanisms and function and discovers hundreds of unique sites in human and yeast mRNAs and snoRNAs.
Journal ArticleDOI
Iridium-Catalyzed Direct Hydroarylation of Glycals via C–H Activation: Ligand-Controlled Stereoselective Synthesis of α- and β-C-Glycosyl Arenes
TL;DR: Diastereoselective direct hydroarylation of glycals with aromatic compounds was realized by use of an iridium/binap catalyst, giving the corresponding C-glycosyl compounds in high yields.
Journal ArticleDOI
Emerging Organometallic Methods for the Synthesis of C-Branched (Hetero)aryl, Alkenyl, and Alkyl Glycosides: C-H Functionalization and Dual Photoredox Approaches.
TL;DR: Recent developments in the synthesis of C -branched aryl/alkenyl/alkyl glycosides through transition-metal catalyzed C-H functionalization and photoredox-nickel dual catalysis are highlighted.
Journal ArticleDOI
Copper‐Catalyzed Regioselective Direct C–H Thiolation and Thiocyanation of Uracils
Medena Noikham,Sirilata Yotphan +1 more
Journal ArticleDOI
One-Pot Regioselective and Stereoselective Synthesis of C-Glycosyl Amides from Glycals Using Vinyl Azides as Glycosyl Acceptors.
TL;DR: The reaction of glycals containing good leaving groups with aromatic vinyl azides to give α- C-glycosyl amides in good yields is described, and an iminodiazonium intermediate is generated by the attack of the vinyl azide onto the glycal under Lewis acid conditions.
References
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Journal ArticleDOI
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
TL;DR: New nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to provide increased response rates and reduced side effects are reviewed.
Journal ArticleDOI
Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
Thomas M. Carlile,Maria F. Rojas-Duran,Boris Zinshteyn,Hakyung Shin,Kristen M. Bartoli,Wendy V. Gilbert +5 more
TL;DR: Gilbert et al. as discussed by the authors used pseudouridylation detection on a genome-wide scale, leading to the identification of pseudouridine in messenger RNAs as well as almost 100 new sites in non-coding RNAs.
Journal ArticleDOI
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schraga Schwartz,Douglas A. Bernstein,Maxwell R. Mumbach,Marko Jovanovic,Rebecca H. Herbst,Brian X. León-Ricardo,Jesse M. Engreitz,Mitchell Guttman,Rahul Satija,Eric S. Lander,Gerald R. Fink,Aviv Regev,Aviv Regev,Aviv Regev +13 more
TL;DR: In this paper, the authors develop Ψ-seq for transcriptome-wide quantitative mapping of pseudouridine and identify hundreds of unique sites in human and yeast mRNAs and snoRNAs.
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schraga Schwartz,Douglas A. Bernstein,Maxwell R. Mumbach,Marko Jovanovic,Rebecca H. Herbst,Brian X. León-Ricardo,Jesse M. Engreitz,Mitchell Guttman,Rahul Satija,Eric S. Lander,Gerald R. Fink,Aviv Regev,Aviv Regev,Aviv Regev +13 more
TL;DR: This work identifies an enhanced, transcriptome-wide scope for pseudouridine and methods to dissect its underlying mechanisms and function and discovers hundreds of unique sites in human and yeast mRNAs and snoRNAs.
Journal ArticleDOI
Recent researches in triazole compounds as medicinal drugs.
TL;DR: This work systematically reviewed the recent researches and developments of the whole range of triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic, anticonvulsant, antiparasitic, antidiabetic and anti-obesitic.
Related Papers (5)
Regio- and stereo-selective synthesis of aryl 2-deoxy-C-glycopyranosides by palladium-catalyzed Heck coupling reactions of glycals and aryl iodides
Hou-Hua Li,Xin-Shan Ye +1 more