Journal ArticleDOI
Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats.
Massimo Collino,Elisa Benetti,Gianluca Miglio,Sara Castiglia,Arianna Carolina Rosa,Manuela Aragno,Christoph Thiemermann,Roberto Fantozzi +7 more
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TLDR
It is reported herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2011-01-15. It has received 48 citations till now. The article focuses on the topics: Kidney metabolism & Reperfusion injury.read more
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Physiological functions of peroxisome proliferator-activated receptor β.
Jaap G Neels,Paul Grimaldi +1 more
TL;DR: Evidence is summarized for the implication of PPARβ in the regulation of development, metabolism, and inflammation in several tissues, including skeletal muscle, heart, skin, and intestine that indicates that pharmacological activation ofPPARβ could be envisioned as a therapeutic option for the correction of metabolic disorders and a variety of inflammatory conditions.
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Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2.
TL;DR: It is concluded that exosomal miR-25-3p from MSCs alleviated MI by targeting pro-apoptotic proteins and EZH2 and inhibition of EZh2 or overexpression of miR -25- 3p in cardiomyocytes was sufficient to confer cardioprotective effects in vitro and in vivo.
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Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.
TL;DR: The aim of the present review is to present in detail the diversity of PPARβ/δ function, focusing on the different information gained at the systemic level, and describing the global and unbiased approaches that combine a systems view with molecular understanding.
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Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
Massimo Collino,Mara Rogazzo,Alessandro Pini,Elisa Benetti,Arianna Carolina Rosa,Fausto Chiazza,Roberto Fantozzi,Daniele Bani,Emanuela Masini +8 more
TL;DR: It is reported herein that rhRLX protects the kidney against I/R injury by a mechanism that involves changes in nitric oxide signalling pathway.
Journal ArticleDOI
Sodium Intake Regulates Glucose Homeostasis through the PPARδ/Adiponectin-Mediated SGLT2 Pathway
Yu Zhao,Peng Gao,Fang Sun,Qiang Li,Jing Chen,Hao Yu,Li Li,Xing Wei,Hongbo He,Zongshi Lu,Xiao Wei,Bin Wang,Yuanting Cui,Shiqiang Xiong,Qianhui Shang,Aimin Xu,Yu Huang,Daoyan Liu,Zhiming Zhu +18 more
TL;DR: It is reported that high sodium intake remarkably increased natriuresis in wild-type mice, but this effect was blunted in adipose-specific PPARδ knockout mice and diabetic mice, providing insights into the distinctive role of the PParδ/adiponectin/SGLT2 pathway in the regulation of sodium and glucose homeostasis.
References
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Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
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Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.
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The Mechanisms of Action of PPARs
Joel P. Berger,David E. Moller +1 more
TL;DR: The current state of knowledge regarding the molecular mechanisms of PPAR action and the involvement of the PPARs in the etiology and treatment of several chronic diseases is presented.
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Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
Won K. Han,Won K. Han,Veronique Bailly,Veronique Bailly,Rekha Abichandani,Rekha Abichandani,Ravi Thadhani,Ravi Thadhani,Joseph V. Bonventre,Joseph V. Bonventre +9 more
TL;DR: A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.
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SOCS proteins, cytokine signalling and immune regulation.
TL;DR: This review brings together data from recent studies on SOCS proteins and their role in immunity, and proposes a cohesive model of how cytokine signalling regulates immune-cell function.