PET/CT in Oncology: Current Status and Perspectives
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TLDR
This review discusses the challenges and obstacles in clinical adoption of 18F-FDG imaging and discusses a variety of additional molecular imaging approaches that can be used for cancer phenotyping with PET.Abstract:
The discovery of the Warburg effect in the early twentieth century followed by the development of the fluorinated glucose analogue 18F-fluorodeoxyglucose (18F-FDG) and the invention of positron emission tomographs laid the foundation of clinical PET/CT. This review discusses the challenges and obstacles in clinical adoption of this technique. We then discuss advances in instrumentation, including the critically important introduction of PET/CT and current PET/CT protocols. Moreover, we provide evidence for the clinical utility of PET/CT for patient management and its potential impact on patient outcome, and address its cost and cost-effectiveness. Although this review largely focuses on 18F-FDG imaging, we also discuss a variety of additional molecular imaging approaches that can be used for cancer phenotyping with PET. Throughout this review we emphasize the critical contributions of CT to the strength of PET/CT.read more
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Phantom-based image quality assessment of clinical 18 F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT
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