Peyer's Patches in the Human Gut:
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This article is published in Journal of the Royal Society of Medicine.The article was published on 1965-09-01 and is currently open access. It has received 44 citations till now.read more
Citations
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Roundtrip Ticket for Secretory IgA: Role in Mucosal Homeostasis?
TL;DR: In terms of humoral immunity at mucosal surfaces, SIgA appears to combine properties of a neutralizing agent (immune exclusion) and of a mucosal immunopotentiator inducing effector immune responses in a noninflammatory context favorable to preserve local homeostasis of the gastrointestinal tract.
Journal ArticleDOI
Peyer's patches: organizing B-cell responses at the intestinal frontier
Andrea Reboldi,Jason G. Cyster +1 more
TL;DR: Current understanding of how PPs foster B‐cell encounters with antigen is reviewed, how they favor isotype switching to the secretory IgA isotype, and how their GC responses may uniquely contribute to mucosal immunity are reviewed.
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Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans
TL;DR: This review has compiled and critically reviewed data from numerous studies of GI anatomy and physiology of various animal species commonly used in drug delivery modeling, commenting on the appropriateness of these animals for in vivo comparison and extrapolation to humans.
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Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery.
TL;DR: This review of particle uptake by Peyer’s patches depends on several different factors that are the physicochemical properties of the particles, the physiopathological state of the animal, the analytical method used to evaluate the uptake and the experimental model.
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Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development.
Hamid A. Merchant,Emma L. McConnell,Fang Liu,Chandrasekaran Ramaswamy,Rucha P Kulkarni,Abdul Basit,Sudaxshina Murdan +6 more
TL;DR: Investigation of post-mortem in healthy guinea pigs, rabbits and pigs to assess their suitability for pre-clinical studies indicated the potential utility of these animal species in oral and colonic vaccination.
References
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Number, size, and distribution of Peyer's patches in the human small intestine Part I The development of Peyer's patches
TL;DR: The present study was undertaken to find out how many patches there are in the normal human gut and to investigate what happens to them before and after birth.