Phenol-soluble modulins and staphylococcal infection
Andreas Peschel,Michael Otto +1 more
TLDR
Recent progress made in understanding of the biochemical and genetic properties of PSMs and their role in S. aureus pathogenesis are discussed, and potential avenues to target PSMs for the development of anti-staphylococcal drugs are suggested.Abstract:
Staphylococcus aureus is an important human pathogen and a leading cause of death worldwide. Phenol-soluble modulins (PSMs) have recently emerged as a novel toxin family defining the virulence potential of highly aggressive S. aureus isolates. PSMs have multiple roles in staphylococcal pathogenesis, causing lysis of red and white blood cells, stimulating inflammatory responses and contributing to biofilm development and the dissemination of biofilm-associated infections. Moreover, the pronounced capacity of PSMs to kill human neutrophils after phagocytosis might explain failures in the development of anti-staphylococcal vaccines. Here, we discuss recent progress made in our understanding of the biochemical and genetic properties of PSMs and their role in S. aureus pathogenesis, and suggest potential avenues to target PSMs for the development of anti-staphylococcal drugs.read more
Citations
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Implant infections: adhesion, biofilm formation and immune evasion
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Methicillin-resistant Staphylococcus aureus.
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Staphylococcus aureus biofilm: a complex developmental organism.
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