Journal ArticleDOI
Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.
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TLDR
Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.Abstract:
Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol extracts of Psoralea corylifolia by bioactivity-guided fractionation. The structures of bakuchiol (1), bavachinin (2), neobavaisoflavone (3), corylifol A (4), corylin (5), isobavachalcon (6), and bavachin (7) were determined by spectroscopic analysis (1H-, 13C- NMR and MS). We demonstrated that compounds 1-7 showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 4.57 ± 0.45, 3.02 ± 0.53, 2.77 ± 0.02, 0.81 ± 0.15, 1.37 ± 0.45, 2.45 ± 0.13, and 4.89 ± 0.05 µΜ, respectively. These compounds also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells. Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.read more
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Journal ArticleDOI
The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review.
TL;DR: This paper systematically summarized literatures on the chemical constituents and biological activities of P. corylifolia, which provided useful information for the further research and development toward this potent medicinal plant.
Journal ArticleDOI
Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response.
Yung Li Hung,Shih-Hua Fang,Shu-Chi Wang,Wei-Chung Cheng,Po Len Liu,Chia Cheng Su,Chi Shuo Chen,Ming-Yii Huang,Kuo Feng Hua,Kun Hung Shen,Kun Hung Shen,Yu Ting Wang,Katsuhiko Suzuki,Chia-Yang Li +13 more
TL;DR: The experimental results show the anti-inflammatory properties of corylin on LPS-induced inflammation and sepsis, and could potentially be a novel anti- inflammatory and immunosuppressive drug candidate in the treatment ofsepsis and septic shock.
Journal ArticleDOI
Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways
TL;DR: The inhibitory ability of DSF-52 on microglia- mediated neuroinflammation may offer a novel neuroprotective modality and could be potentially useful in inflammation-mediated neurodegenerative diseases.
Journal ArticleDOI
Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages
Yung Li Hung,Shu-Chi Wang,Katsuhiko Suzuki,Shih-Hua Fang,Chi Shuo Chen,Wei-Chung Cheng,Chia Cheng Su,Hsin Chih Yeh,Hung-Pin Tu,Po Len Liu,Ming-Yii Huang,Chia-Yang Li +11 more
TL;DR: The experimental results indicated anti-inflammatory effects of bavachin exhibit attenuation of LPS-induced inflammation and inhibit activation of NLRP3 inflammasome in macrophages, suggesting that bavchin might have potential in treating inflammatory and autoimmune diseases.
Journal ArticleDOI
Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia
Ming-Yii Huang,Chia-En Tu,Shu-Chi Wang,Yung-Li Hung,Chia-Cheng Su,Chia-Cheng Su,Shih-Hua Fang,C.H. Chen,Po-Len Liu,Wei-Chung Cheng,Yu-Wei Huang,Chia-Yang Li +11 more
TL;DR: The experimental results demonstrated that corylin suppressed the production of NO and proinflammatory cytokines by LPS-activated BV2 cells, suggesting that c Corylin might have potential in treating brain inflammation and attenuating the progression of neurodegeneration diseases.
References
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Journal ArticleDOI
IL-6 is required for airway mucus production induced by inhaled fungal allergens.
Wendy A. Neveu,Jenna B. Allard,Oliver Dienz,Matthew J. Wargo,Gennaro Ciliberto,Laurie A. Whittaker,Mercedes Rincon +6 more
TL;DR: IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion.
Journal ArticleDOI
A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma.
Mariateresa Fulciniti,Teru Hideshima,Claudine Vermot-Desroches,Samantha Pozzi,Puru Nanjappa,Zhenxin Shen,Nipun Patel,Ernest S. Smith,Wei Wang,Rao Prabhala,Yu-Tzu Tai,Pierfrancesco Tassone,Kenneth C. Anderson,Nikhil C. Munshi +13 more
TL;DR: In vitro and in vivo anti-multiple myeloma activity of monoclonal antibody 1339, a high-affinity fully humanized anti-interleukin 6 mAb (immunoglobulin G1), alone and in combination with conventional and novel anti- Multiple Myeloma agents, as well as its effect on bone turnover are confirmed.