Journal ArticleDOI
Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities
TLDR
Anti-inflammatory activities of these compounds were determined by measuring nitric oxide levels in the medium using murine microglia BV-2 cells on the basis of the expanded understanding that inflammation is a crucial cause of tumor progression.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2012-10-01. It has received 34 citations till now. The article focuses on the topics: Acorus gramineus.read more
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Recent advances in research on lignans and neolignans
TL;DR: This review describes 564 of the latest examples of naturally occurring lignans and neolignans, and their glycosides in some cases, which have been isolated between 2009 and 2015 and highlights the biosynthesis and total synthesis of some important ones.
Journal ArticleDOI
The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
Xiao-Xiao Huang,Chen-Chen Zhou,Ling-Zhi Li,Fei-Fei Li,Li-Li Lou,Dian-Ming Li,Takshi Ikejima,Ying Peng,Shao-Jiang Song,Shao-Jiang Song +9 more
TL;DR: Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs, together with 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.
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Making natural products from renewable feedstocks: back to the roots?
TL;DR: This review highlights the utilization of biomass-derived building blocks in the total synthesis of natural products and the emerging trend of turning away from petrochemically derived starting materials back to bio-based resources just as seen in the early days of total synthesis.
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Tatanan A from the Acorus calamus L. root inhibited dengue virus proliferation and infections.
Xingang Yao,Ling Yun,Guo Songxin,Wenyu Wu,Shijun He,Qing Zhang,Min Zou,Kutty Selva Nandakumar,Xiaoguang Chen,Shuwen Liu +9 more
TL;DR: Tatanan A was found to be a novel natural DENV inhibitor and a potential candidate for the treatment of DENV infectious disease.
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Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis.
Mohammad Hosein Farzaei,Mohammad Hosein Farzaei,Fatemeh Farzaei,Maziar Gooshe,Zahra Abbasabadi,Nima Rezaei,Nima Rezaei,Amir Hossein Abdolghaffari +7 more
TL;DR: This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA and evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations.
References
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New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Journal Article
Why cancer and inflammation
TL;DR: This review will discuss the reflexive relationship between cancer and inflammation with particular focus on how considering the role of inflammation in physiologic processes such as the maintenance of tissue homeostasis and repair may provide a logical framework for understanding the connection between the inflammatory response and cancer.
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Nitric oxide: discovery and impact on clinical medicine:
TL;DR: An overview of the new understanding that NO has brought to physiology and pathophysiology, with particular emphasis on the therapeutic possibilities that have arisen as a consequence.
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Intramolecular regioselective insertion into unactivated prochiral carbon-hydrogen bonds with diazoacetates of primary alcohols catalyzed by chiral dirhodium(II) carboxamidates. Highly enantioselective total synthesis of natural lignan lactones
TL;DR: In this paper, the chiral Rh2(MPPIM)4 catalysts were applied to fully aliphatic systems resulting in the formation of β-substituted-γ-butyrolactones with high regiocontrol and with 93−96% ee.