Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis.
Sophie Cornillon,Emmanuel Pech,Mohammed Benghezal,Kissia Ravanel,Erin C. Gaynor,François Letourneur,Franz Bruckert,Pierre Cosson +7 more
TLDR
Results indicate that the Phg1 protein is involved in the adhesion of Dictyostelium to various substrates, a crucial event of phagocytosis and demonstrate the usefulness of a genetic approach to dissect the molecular events involved in that process.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-11-03 and is currently open access. It has received 203 citations till now. The article focuses on the topics: Phagocytosis & Transmembrane protein.read more
Citations
More filters
Journal ArticleDOI
Phagocytosis of Microbes: Complexity in Action
TL;DR: This review examines this complexity and describes how during recognition, multiple receptors are simultaneously engaged to mediate internalization, activate microbial killing, and induce the production of inflammatory cytokines and chemokines.
Journal ArticleDOI
Phagocytosis and the actin cytoskeleton
Robin C. May,Laura M. Machesky +1 more
TL;DR: A wide diversity of 'effector molecules' are now implicated in actin-remodelling downstream of phagocytic receptors, such as the involvement of phosphoinostide lipids and multicomponent signalling complexes in transducing signals from phagocytetic receptors to the cytoskeleton.
Journal ArticleDOI
Life, death and autophagy.
TL;DR: The role of autophagy in cell death is reviewed and howAutophagy interfaces with other forms of cell death including apoptosis and necrosis is examined, as well as engulfment and inflammation.
Journal ArticleDOI
Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future
TL;DR: A genome‐wide search of potential novel ITIM‐containing molecules in humans, mice, frogs, birds, and flies and a comparative analysis of potential ITIMs in major animal phyla are found found, finding a surprisingly high number of potentialITIMs, having a great diversity of extracellular domains, and being expressed by a variety of immune and non‐immune cells.
Journal ArticleDOI
The Phagosome: Compartment with a License to Kill
TL;DR: Research into phagosome biogenesis has flourished in recent years – the purpose of this review is to give a glimpse of where this research stands, with emphasis on the cell biology of macrophage phagosomes.
References
More filters
Journal ArticleDOI
Fc RECEPTOR BIOLOGY
TL;DR: In this paper, a review of membrane Fc receptors (FcR) of the immunoglobulin superfamily is presented, focusing on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed.
Journal ArticleDOI
Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus
TL;DR: Observations suggest that phagolysosome formation is a highly dynamic process that involves the gradual and regulated acquisition of markers from endocytic organelles.
Journal ArticleDOI
Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA.
Adam Kuspa,William F. Loomis +1 more
TL;DR: Electroporating BamHI or EcoRI together with pyr5-6 plasmids cut with the same enzyme stimulates the efficiency of transformation in Dictyostelium discoideum more than 20-fold over the rate seen when plasmid DNA alone is introduced.
Journal ArticleDOI
The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils
Friedemann Kiefer,John H. Brumell,Nadia Al-Alawi,Sylvain Latour,Alec M. Cheng,André Veillette,Sergio Grinstein,Tony Pawson,Tony Pawson +8 more
TL;DR: Results suggest that Syk has specific physiological roles in signaling from FcγRs in neutrophils and macrophages and raise the possibility that in vivo, Syk is involved in signaling events other than those mediated by immunoreceptors.
Journal ArticleDOI
Programmed cell death in Dictyostelium
Sophie Cornillon,Colette Foa,Jean Davoust,Nathalie Buonavista,Julian D. Gross,Pierre Golstein +5 more
TL;DR: These traits exhibit some similarity to those of previously described non-apoptotic and apoptotic PCD, suggesting the hypothesis of a single core molecular mechanism of PCD emerging in evolution before the postulated multiple emergences of multicellularity.