Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography.
TLDR
Detailed examination of the atomic displacements and dihedral angle changes of the retinal chromophore involved in the interconversion among these isomers suggests the mechanism of isomerization efficiency.About:
This article is published in Biophysical Journal.The article was published on 2007-06-15 and is currently open access. It has received 56 citations till now. The article focuses on the topics: Photoisomerization & Rhodopsin.read more
Citations
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Journal ArticleDOI
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.
Oliver P. Ernst,David T. Lodowski,Marcus Elstner,Peter Hegemann,Leonid S. Brown,Hideki Kandori +5 more
TL;DR: Rhodopsins found in Eukaryotes, Bacteria, and Archaea consist of opsin apoproteins and a covalently linked retinal which is employed to absorb photons for energy conversion or the initiation of intra- or intercellular signaling.
Journal ArticleDOI
Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins
TL;DR: The main structural difference between proteins and other chain molecules is that, under physiological conditions, proteins sample a significantly narrower distribution of conformations compared to disordered polymers, which may facilitate the diffusion of oxygen into the heme cavity of myoglobin or the permeation of ions across selectivity filters in ion channels.
Journal ArticleDOI
Structural insights into agonist-induced activation of G-protein-coupled receptors
Xavier Deupi,Jörg Standfuss +1 more
TL;DR: A transmission switch links agonist binding to the movement of TM5 and TM6 through the rearrangement of the TM3-TM5-TM6 interface, and possibly constitutes a common theme of GPCR activation.
Journal ArticleDOI
Modern homology modeling of G-protein coupled receptors: which structural template to use?
TL;DR: The results suggest that better templates than those currently available are required by the majority of these GPCRs to generate homology models that are accurate enough for simple virtual screening aimed at computer-aided drug discovery.
Journal ArticleDOI
X-ray structure breakthroughs in the GPCR transmembrane region.
Sid Topiol,Michael Sabio +1 more
TL;DR: Some of the recent findings in this area are summarized and an initial perspective of the emerging opportunities, possible limitations, and remaining questions are provided.
References
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The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
Tetsuji Okada,Minoru Sugihara,Ana-Nicoleta Bondar,Ana-Nicoleta Bondar,Marcus Elstner,Peter Entel,Volker Buss +6 more
TL;DR: A new high-resolution structure is reported for bovine rhodopsin, the visual pigment in rod photoreceptor cells, and a theoretical study of the chromophore geometry has been carried out using combined quantum mechanics/force field molecular dynamics.
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Structure of bovine rhodopsin in a trigonal crystal form
TL;DR: The structure of bovine rhodopsin supports a mechanism for the activation, initiated by photo-isomerisation of the chromophore to its all-trans form, that involves pivoting movements of kinked helices, which, while maintaining hydrophobic contacts in the membrane interior, can be coupled to amplified translation of the helix ends near the membrane surfaces.
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Nature of the primary photochemical events in rhodopsin and bacteriorhodopsin
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Crystallographic Analysis of Primary Visual Photochemistry
Hitoshi Nakamichi,Tetsuji Okada +1 more
TL;DR: Spectroscopic studies at low temperature or with time resolution yielded indirect structural data for this photochemical intermediate, and Resonance Raman spectra of trapped bathorhodopsin indicated a strongly distorted chromophore in the region where the isomerization has taken place.
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Ab Initio Photoisomerization Dynamics of a Simple Retinal Chromophore Model
Thom Vreven,Fernando Bernardi,Marco Garavelli,Massimo Olivucci,Michael A. Robb, ,† and,H. Bernhard Schlegel +5 more
TL;DR: The photoisomerization of the 11-cis-retinal-protonated Schiff base PSB11 (the chromophore of rhodopsin) to its all-trans isomer (PSBT) is the primary event of vision.