Journal ArticleDOI
Photopolymerization of cell-encapsulating hydrogels: crosslinking efficiency versus cytotoxicity.
TLDR
Cytocompatibility may be compromised by unnecessarily prolonging exposure to cytotoxic free radicals or inadvertently enhancing the instantaneous dose of radicals in solution, both of which are dependent on the PI type/concentration and irradiation intensity.About:
This article is published in Acta Biomaterialia.The article was published on 2012-05-01. It has received 279 citations till now. The article focuses on the topics: Self-healing hydrogels & Light intensity.read more
Citations
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Journal ArticleDOI
The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability
TL;DR: The use and optimization of VA-086 as a photo-initiator with enhanced biocompatibility compared to the conventional Irgacure 2959 is proposed and Mechanically stable cell-laden gelatin methacrylamide scaffolds with high cell viability (>97%) could be printed.
Journal ArticleDOI
Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair.
Barbara J. Klotz,Debby Gawlitta,Antoine J.W.P. Rosenberg,Jos Malda,Ferry P.W. Melchels,Ferry P.W. Melchels +5 more
TL;DR: G gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention and could be used to accelerate the development of clinically relevant applications.
Journal ArticleDOI
In situ forming injectable hydrogels for drug delivery and wound repair.
TL;DR: This review highlights injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair and provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body.
Journal ArticleDOI
Advances in crosslinking strategies of biomedical hydrogels
TL;DR: The commonly used crosslinking method for hydrogel synthesis involving physical and chemical crosslinks is presented and their current progress and future perspectives are summarized.
Journal ArticleDOI
3D Cell Culture in Alginate Hydrogels
TL;DR: Delayed gelling, injectable, alginate systems show utility in the translation of in vitro cell culture to in vivo tissue engineering applications, and several commercial products based onAlginate are being used as 3D cell culture systems that also demonstrate the possibility of replacing or regenerating tissue.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
Journal ArticleDOI
Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.
Journal ArticleDOI
Novel crosslinking methods to design hydrogels
Wim E. Hennink,C.F. van Nostrum +1 more
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.
Journal ArticleDOI
Photopolymerizable hydrogels for tissue engineering applications.
Kytai T. Nguyen,Jennifer L. West +1 more
TL;DR: Advantages of photopolymerization of hydrogels are presented, the photoinitiators and materials in current use are described and the applications that have been investigated are summarized.
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Photopolymerizable hydrogels for tissue engineering applications.
Kytai T. Nguyen,Jennifer L. West +1 more