Journal ArticleDOI
Physicochemical properties of film-coated melt-extruded pellets.
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The current study demonstrated film-coating to be an efficient process for providing melt-extruded beads with pH-dependent drug release properties that were stable upon storage at accelerated conditions.Abstract:
The purpose of this study was to investigate the physicochemical properties of poly(ethylene oxide) (PEO) and guaifenesin containing beads prepared by a melt-extrusion process and film-coated with a methacrylic acid copolymer. Solubility parameter calculations, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), modulated differential scanning calorimetry (MDSC), X-ray powder diffraction (XRPD) and high performance liquid chromatography (HPLC) were used to determine drug/polymer miscibility and/or the thermal processibility of the systems. Powder blends of guaifenesin, PEO and functional excipients were processed using a melt-extrusion and spheronization technique and then film-coated in a fluidized bed apparatus. Solubility parameter calculations were used to predict miscibility between PEO and guaifenesin, and miscibility was confirmed by SEM and observation of a single melting point for extruded drug/polymer blends during MDSC investigations. The drug was stable following melt-extrusion as determined by TGA and HPLC; however, drug release rate from pellets decreased upon storage in sealed HDPE containers with silica desiccants at 40 degrees C/75% RH. The weight loss on drying, porosity and tortuosity determinations were not influenced by storage. Recrystallization of guaifenesin and PEO was confirmed by SEM and XRPD. Additionally, the pellets exhibited a change in adhesion behaviour during dissolution testing. The addition of ethylcellulose to the extruded powder blend decreased and stabilized the drug release rate from the thermally processed pellets. The current study also demonstrated film-coating to be an efficient process for providing melt-extruded beads with pH-dependent drug release properties that were stable upon storage at accelerated conditions.read more
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Properties of polymers
TL;DR: In this article, the role of phenolic antioxidants and their products in the long-term properties of polyolefins is discussed, as well as their role in the reinforcement of rubber by carbon black.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Applications of hot-melt extrusion for drug delivery.
TL;DR: The range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration are reviewed.
Journal ArticleDOI
Hot-melt extrusion – basic principles and pharmaceutical applications
TL;DR: An in-depth analysis and discussion of the formulation and processing aspects of hot-melt extrusion to a variety of dosage forms and drug substances are provided.
Journal ArticleDOI
Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations.
Balázs Démuth,Zsombor Kristóf Nagy,Attila Balogh,Tamás Vigh,György Marosi,Geert Verreck,I. Van Assche,Marcus E. Brewster +7 more
TL;DR: The aim of this review is to focus on the conversion of amorphous solid dispersions into tablets highlighting results from various viewpoints.
References
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TL;DR: In this paper, the authors present a method for the synthesis of organic compounds using Spectroscopic methods and Spectral Spectral Methods (SSTM) with a focus on alicyclic and aliphatic compounds.
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TL;DR: A text-book of Practical Organic Chemistry including Qualitative Organic Analysis by Dr Arthur I Vogel as mentioned in this paper, intended as a comprehensive laboratory manual for students of organic chemistry, gives a full and valuable description of organic chemical technique, details of preparation of more than six hundred compounds, and a scheme of qualitative organic analysis.
Journal ArticleDOI
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TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.
Journal ArticleDOI
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Bruno C. Hancock,George Zografi +1 more
TL;DR: The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms and some of the most common methods that can be used to measure them are described.
Journal ArticleDOI
Biodegradable microspheres for protein delivery.
Vivek Ranjan Sinha,Aman Trehan +1 more
TL;DR: This review presents the outstanding contributions in field of biodegradable microspheres as protein delivery systems, their methods of preparation, drug release, stability, interaction with immune system and regulatory considerations.