Journal ArticleDOI
Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium.
TLDR
The glycopeptide antibiotic agents vancomycin and teicoplanin are useful in the treatment of severe infections due to gram-positive bacteria.Abstract:
THE glycopeptide antibiotic agents vancomycin and teicoplanin are useful in the treatment of severe infections due to gram-positive bacteria.1 2 3 Staphylococci, streptococci, and enterococci are a...read more
Citations
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Journal ArticleDOI
The Crisis in Antibiotic Resistance
TL;DR: Mechanisms such as antibiotic control programs, better hygiene, and synthesis of agents with improved antimicrobial activity need to be adopted in order to limit bacterial resistance.
Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
The life and times of the Enterococcus.
TL;DR: Enterococci are important human pathogens that are increasingly resistant to antimicrobial agents, including resistance to cephalosporins, clindamycin, tetracycline, and penicillinase-resistant penicillins such as oxacillin, among others.
Journal ArticleDOI
An overview of nosocomial infections, including the role of the microbiology laboratory.
T G Emori,R P Gaynes +1 more
TL;DR: An estimated 2 million patients develop nosocomial infections in the United States annually and the growing number of antimicrobial agent-resistant organisms is troublesome, particularly vancomycin-resistant CoNS and Enterococcus spp.
Journal ArticleDOI
Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR.
TL;DR: A PCR assay that allows simultaneous detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci was developed and offered a specific and rapid alternative to antibiotic susceptibility tests, in particular for detection of low-level vancomycin resistance.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Detection of specific sequences among DNA fragments separated by gel electrophoresis.
TL;DR: This paper describes a method of transferring fragments of DNA from agarose gels to cellulose nitrate filters that can be hybridized to radioactive RNA and hybrids detected by radioautography or fluorography.
Journal ArticleDOI
Vancomycin-resistant enterococci
TL;DR: Enterococci associated with cultures obtained from burn patients have been on the increase, worldwide, over the past decade and are now among the four most common nosocomial pathogens in the US and have been called the ‘nosocomial infections of the 1990s’.