Platelet transfusions for patients with haematological malignancies: who needs them?
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TLDR
This review summarizes the recent evidence regarding the clinical use of platelet transfusions in haematology patients, concentrating on the topics that still continue to provoke debate, including the optimal dose for platelets transfusions and the relative safety of a ‘therapeutic only’ Platelet transfusion strategy compared to the use of prophylactic transfusions.Abstract:
Summary
The goal of platelet transfusions is to prevent severe and life-threatening bleeding in patients with thrombocytopenia. This aim needs to be balanced against the risks associated with platelet transfusions as well as the challenge of maintaining an adequate supply. This review summarizes the recent evidence regarding the clinical use of platelet transfusions in haematology patients, concentrating on the topics that still continue to provoke debate. These include the optimal dose for platelet transfusions and the relative safety of a ‘therapeutic only’ platelet transfusion strategy compared to the use of prophylactic platelet transfusions. The type of platelet product has been the subject of two recent systematic reviews. The results of these reviews will be discussed as well as their implications for current practice.read more
Citations
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Journal ArticleDOI
Guidelines for the Use of Platelet Transfusions
Lise J Estcourt,Janet Birchall,Shubha Allard,Stephen J Bassey,Peter Hersey,Jonathan P. Kerr,Andrew D Mumford,Simon J. Stanworth,Hazel Tinegate +8 more
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Concepts of blood transfusion in adults
TL;DR: Institutional experience and national databases suggest that a restrictive blood transfusion approach is being increasingly implemented as best practice.
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Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation.
Lise J Estcourt,Simon J. Stanworth,Carolyn Doree,Sally Hopewell,Michael F. Murphy,Alan Tinmouth,Nancy M. Heddle +6 more
TL;DR: The most effective use of prophylactic platelet transfusion for the prevention of bleeding in patients with haematological disorders undergoing chemotherapy or stem cell transplantation is determined.
Journal ArticleDOI
Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial
Lynne Uhl,Lynne Uhl,Susan F. Assmann,Taye H. Hamza,Ryan W. Harrison,Terry Gernsheimer,Terry Gernsheimer,Sherrill J. Slichter,Sherrill J. Slichter +8 more
TL;DR: Transfusion of either platelets or red blood cells on days with bleeding was often not sufficient to change bleeding outcomes on the following day, and platelet transfusions may not prevent bleeding, so other risk factors may be involved.
Journal ArticleDOI
Thrombocytopenia and platelet transfusion in UK critical care: a multicenter observational study.
TL;DR: In this article, a prospective multicenter observational study of all sequentially admitted patients to UK general intensive care units (ICUs) over 8 weeks, daily data were collected throughout admission on frequency of thrombocytopenia and use of PLT transfusions, in addition to clinical outcomes, including bleeding.
References
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Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal Article
Cochrane Handbook for Systematic Reviews of Interventions
Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration
Journal ArticleDOI
Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review.
Amit X. Garg,Neill K. J. Adhikari,Heather McDonald,M. Patricia Rosas-Arellano,Philip J. Devereaux,Joseph Beyene,Justina Sam,R. Brian Haynes +7 more
TL;DR: Improvement in practitioner performance was associated with CDSSs that automatically prompted users compared with requiring users to activate the system and studies in which the authors were not the developers, as well as other factors.
Journal ArticleDOI
WHO Handbook for Reporting Results of Cancer Treatment
TL;DR: "Diagnostic Electron Microscopy volume 3", in summary, will provide histopatholo-gists with access to or an interest in electron microscopy with authoritative treatments of several major areas of tumour and non-tumour application: it will be particularly welcomed by those specializing in neoplasia.
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