Journal ArticleDOI
Polo-like kinases and the orchestration of cell division.
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TLDR
Polo-like kinases are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis and their targeting to different cellular structures through interactions with phosphorylated docking proteins is uncovered.Abstract:
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular structures through interactions with phosphorylated docking proteins. Moreover, information is emerging on the substrate specificity of Plks and the role of individual substrates in M-phase progression.read more
Citations
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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
TL;DR: Depletion of VISA inhibits virus-triggered and RIG-I-mediated activation of IRF-3, NF-kappaB, and the IFN-beta promoter, suggesting that VISA plays a central role in virus- Triggered TLR3-independent IFn-beta signaling.
Journal ArticleDOI
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
Ji Luo,Michael J. Emanuele,Danan Li,Chad J. Creighton,Michael R. Schlabach,Thomas F. Westbrook,Kwok-Kin Wong,Stephen J. Elledge +7 more
TL;DR: A pathway involving the mitotic kinase PLK1, the anaphase-promoting complex/cyclosome, and the proteasome that, when inhibited, results in prometaphase accumulation and the subsequent death of Ras mutant cells is described.
Journal ArticleDOI
Mechanisms of Asymmetric Stem Cell Division
TL;DR: These distinct pathways have been elucidated mostly in Drosophila and show that the way stem cells act is tissue specific and sometimes very different from invertebrates.
Journal ArticleDOI
Chromosomal passengers: conducting cell division
TL;DR: Research into the chromosomal passenger complex, which comprises Aurora-B protein kinase, the inner centromere protein INCENP, survivin and borealin, is providing insights into its functions, which range from chromosome–microtubule interactions to sister chromatid cohesion to cytokinesis.
Journal ArticleDOI
Targeting polo-like kinase 1 for cancer therapy
Klaus Strebhardt,Axel Ullrich +1 more
TL;DR: The structural features of the kinase domain and the unique polo-box domain ofPLK1 that are most suited for drug development are addressed and the current understanding of the therapeutic potential of PLK1 is discussed.
References
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Journal ArticleDOI
Mitotic kinases as regulators of cell division and its checkpoints
TL;DR: An overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission is given.
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Assembly of cell regulatory systems through protein interaction domains.
TL;DR: The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation, but this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior.
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Active and Inactive Protein Kinases: Structural Basis for Regulation
TL;DR: This review summarizes the current understand of the crystal structure Control mechanisms that have been recognized to determination of cAPK and showed the structural importance of Thr-197 or domains that may function in response to second phosphorylation and demonstrated possible roles of messengers.
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The anaphase-promoting complex: proteolysis in mitosis and beyond.
TL;DR: Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin- dependent proteolysis, mediated by the anaphase-promoting complex.
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Centromeres and Kinetochores: From Epigenetics to Mitotic Checkpoint Signaling
TL;DR: Efforts to understand the nature and specification of the centromere have demonstrated that this central element for ensuring inheritance is itself epigenetically determined.