Journal ArticleDOI
Polymeric membranes for guided bone regeneration.
TLDR
Non‐resorbable and resorbable commercially available membranes are described, based on expanded polytetrafluoroethylene, poly(lactic acid), poly(glycolic acid) and theirCopolymers and their copolymers.Abstract:
In this review, different barrier membranes for guided bone regeneration (GBR) are described as a useful surgical technique to enhance bone regeneration in damaged alveolar sites before performing implants and fitting other dental appliances. The GBR procedure encourages bone regeneration through cellular exclusion and avoids the invasion of epithelial and connective tissues that grow at the defective site instead of bone tissue. The barrier membrane should satisfy various properties, such as biocompatibility, non-immunogenicity, non-toxicity, and a degradation rate that is long enough to permit mechanical support during bone formation. Other characteristics such as tissue integration, nutrient transfer, space maintenance and manageability are also of interest. In this review, various non-resorbable and resorbable commercially available membranes are described, based on expanded polytetrafluoroethylene, poly(lactic acid), poly(glycolic acid) and their copolymers. The polyester-based membranes are biodegradable, permit a single-stage procedure, and have higher manageability than non-resorbable membranes; however, they have shown poor biocompatibility. In contrast, membranes based on natural materials, such as collagen, are biocompatible but are characterized by poor mechanical properties and stability due to their early degradation. Moreover, new approaches are described, such as the use of multi-layered, graft-copolymer-based and composite membranes containing osteoconductive ceramic fillers as alternatives to conventional membranes.read more
Citations
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Journal ArticleDOI
Collagen for bone tissue regeneration.
TL;DR: The analysis of the state of the art in the field reveals the presence of innovative techniques for scaffold and material manufacturing that are currently opening the way to the preparation of biomimetic substrates that modulate cell interaction for improved substitution, restoration, retention or enhancement of bone tissue function.
Journal ArticleDOI
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.
Journal ArticleDOI
Recent advances in the development of GTR/GBR membranes for periodontal regeneration--a materials perspective.
Marco C. Bottino,Vinoy Thomas,Gudrun Schmidt,Yogesh K. Vohra,Tien-Min G. Chu,Michael J. Kowolik,Gregg M. Janowski +6 more
TL;DR: It is hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM).
Journal ArticleDOI
Guided bone regeneration: materials and biological mechanisms revisited.
TL;DR: Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration, Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation.
Journal ArticleDOI
Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes
Jiajia Xue,Min He,Hao Liu,Yuzhao Niu,Aileen Crawford,P. D. Coates,Dafu Chen,Rui Shi,Liqun Zhang +8 more
TL;DR: The potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR-GBR strategies is indicated.
References
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Journal ArticleDOI
Bone substitutes: an update.
TL;DR: An overview of bone grafts and graft substitutes available for clinical applications is presented and osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold are provided.
Journal ArticleDOI
Biomimetic materials for tissue engineering.
TL;DR: The surface and bulk modification of biomaterials with cell recognition molecules to design biomimetic materials for tissue engineering and recent advances for the development of biomimetics materials in bone, nerve, and cardiovascular tissue engineering are summarized.
Journal ArticleDOI
Ultrasound-guided percutaneous injection of ethanolamine oleate for hypersplenism. An experimental study in dogs.
TL;DR: In order to evaluate a possible therapy for hypersplenism, an experiment with animals was done and 0.6 ml/kg body weight of 5% ethanolamine oleate was injected percutaneously into the spleen under ultrasound guidance.
Journal ArticleDOI
Regeneration and enlargement of jaw bone using guided tissue regeneration
TL;DR: The results of the study indicate that the biological principle of GTR is highly predictable for ridge enlargement or defect regeneration under the prerequisite of a complication-free healing.
Journal ArticleDOI
Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers.
TL;DR: New type of guided bone regeneration (GBR) membranes were fabricated by polycaprolactone (PCL)/CaCO3 composite nano-fibers with two different PCL to calcium carbonate ( CaCO3) ratios and there is a potential to utilize PCL/CaCO4 composite nano -fiber to GBR membranes.
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