Post-transcriptional Up-regulation of Tsc-22 by Ybx1, a Target of miR-216a, Mediates TGF-β-induced Collagen Expression in Kidney Cells
Mitsuo Kato,Lin Wang,Sumanth Putta,Mei Wang,Hang Yuan,Guangdong Sun,Linda Lanting,Ivan Todorov,John J. Rossi,Rama Natarajan +9 more
TLDR
It is demonstrated that post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-β-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-10-29 and is currently open access. It has received 155 citations till now. The article focuses on the topics: Transforming growth factor beta & Regulation of gene expression.read more
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Mechanisms of Diabetic Complications
TL;DR: The well validated, as well as putative mechanisms involved in the development of diabetic complications are discussed and new fields of research, which warrant further investigation as potential therapeutic targets of the future, will be highlighted.
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Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.
Boris Hinz,Sem H. Phan,Victor J. Thannickal,Marco Prunotto,Alexis Desmoulière,John Varga,Olivier De Wever,Marc Mareel,Giulio Gabbiani +8 more
TL;DR: The origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors are reviewed.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Y-box-binding protein 1 (YB-1) and its functions.
TL;DR: The structure and functions of Y-box binding protein 1 and its homologs are described and the potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed.
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Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy
TL;DR: Specific reduction of renal miR-192 decreases renal fibrosis and improves proteinuria, lending support for the possibility of an anti-miRNA-based translational approach to the treatment of diabetic nephropathy.
References
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
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Prediction of Mammalian MicroRNA Targets
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The SWISS-MODEL Repository and associated resources
TL;DR: The aim of the SWISS-MODEL Repository is to provide access to an up-to-date collection of annotated 3D protein models generated by automated homology modelling for all sequences in Swiss-Prot and for relevant models organisms.