Journal ArticleDOI
Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics
Bobo Gu,Wenbo Wu,Gaixia Xu,Guangxue Feng,Feng Yin,Peter Han Joo Chong,Junle Qu,Ken-Tye Yong,Bin Liu +8 more
TLDR
Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples.Abstract:
Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Photosensitizers for Photodynamic Therapy
TL;DR: The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted and the approaches that combine PDT with other therapeutics and the targeted delivery in cancer cells or tumor tissue are introduced.
Journal ArticleDOI
Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications
Fang Hu,Shidang Xu,Bin Liu +2 more
TL;DR: In this paper, the design principles of aggregation-induced emission (AIE) PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIE PSs to highlight various design strategies and unique features of the latter.
Journal ArticleDOI
Aggregation-Induced Emission (AIE) Dots: Emerging Theranostic Nanolights.
Guangxue Feng,Bin Liu +1 more
TL;DR: The recent advance of AIE dots is summarized and their great potential as theranostic nanolights in biomedical applications is highlighted, with particular interest is AIE photosensitizer dots, which simultaneously show bright fluorescence and high photosensitization, yielding superior performance to commercial photosensitized nanoparticles in image-guided therapy.
Journal ArticleDOI
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy.
TL;DR: In this paper, a review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, to provide intuitive, vivid, and specific insights to the readers.
References
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Journal ArticleDOI
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Jingdong Luo,Zhiliang Xie,Jacky W. Y. Lam,Lin Cheng,Haiying Chen,Chengfeng Qiu,Hoi Sing Kwok,Xiaowei Zhan,Yunqi Liu,Daoben Zhu,Ben Zhong Tang +10 more
TL;DR: Aggregation greatly boosts emission efficiency of the silole, turning it from a weak luminophor into a strong emitter.
Journal ArticleDOI
Aggregation-Induced Emission: Together We Shine, United We Soar!
TL;DR: This paper presents a meta-analysis of the chiral stationary phase transition of Na6(CO3)(SO4)2, a major component of the response of the immune system to Na2CO3.
Journal ArticleDOI
Photodynamic therapy for cancer
TL;DR: PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.
Journal ArticleDOI
Aggregation-induced emission
TL;DR: In this critical review, recent progress in the area ofAIE research is summarized and typical examples of AIE systems are discussed, from which their structure-property relationships are derived.
Journal ArticleDOI
Photodynamic therapy of cancer: An update†‡
Patrizia Agostinis,Kristian Berg,Keith A. Cengel,Thomas H. Foster,Albert W. Girotti,Sandra O. Gollnick,Stephen M. Hahn,Michael R. Hamblin,Michael R. Hamblin,Asta Juzeniene,David Kessel,Mladen Korbelik,Johan Emelian Moan,Johan Emelian Moan,Pawel Mroz,Dominika Nowis,Jacques Piette,Brian C. Wilson,Jakub Golab,Jakub Golab +19 more
TL;DR: The photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells as discussed by the authors, which can prolong survival in patients with inoperable cancers and significantly improve quality of life.