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Journal ArticleDOI

Predicting fluid responsiveness in children: a systematic review.

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TLDR
Static variables did not predict fluid responsiveness in children, which was consistent with evidence in adults, but the evidence for dynamic variables based on plethysmography was inconclusive.
Abstract
BACKGROUND:Administration of fluid to improve cardiac output is the mainstay of hemodynamic resuscitation. Not all patients respond to fluid therapy, and excessive fluid administration is harmful. Predicting fluid responsiveness can be challenging, particularly in children. Numerous hemodynamic vari

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Citations
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Journal ArticleDOI

Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

Scott L. Weiss, +53 more
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Journal ArticleDOI

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Scott L. Weiss, +54 more
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Journal ArticleDOI

Does Respiratory Variation in Inferior Vena Cava Diameter Predict Fluid Responsiveness: A Systematic Review and Meta-Analysis.

TL;DR: Respiratory variation in IVC diameter has limited ability to predict fluid responsiveness, particularly in spontaneously ventilating patients, and clinical context should be taken into account when using IVC ultrasound to help make treatment decisions.
Journal ArticleDOI

Accuracy of Ultrasonographic Measurements of Inferior Vena Cava to Determine Fluid Responsiveness: A Systematic Review and Meta-Analysis.

TL;DR: The aim of this work was to systematically review all the previously published studies assessing the accuracy of the diameter of IVC or its respiratory variations measured through US in predicting fluid responsiveness, and found an extreme heterogeneity of included studies.
References
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Journal ArticleDOI

Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

TL;DR: This study randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy or standard therapy (as a control) before admission to the intensive care unit.
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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

TL;DR: In this article, an evidence-based quality assessment tool called QUADAS was proposed to assess the quality of primary studies of diagnostic accuracy, based on the results of three previously conducted reviews of the diagnostic literature.
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Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality.

TL;DR: A more positive fluid balance both early in resuscitation and cumulatively over 4 days is associated with an increased risk of mortality in septic shock.
Journal ArticleDOI

Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure.

TL;DR: It was concluded that in mechanically ventilated patients with acute circulatory failure related to sepsis, analysis of DeltaPp is a simple method for predicting and assessing the hemodynamic effects of VE, and that DeltaP p is a more reliable indicator of fluid responsiveness than DeltaPs.
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