Journal ArticleDOI
Prediction of motor recovery after stroke: advances in biomarkers
TLDR
The combination of biomarkers can provide clinically useful information when planning the personalised rehabilitation of a patient and ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice.Abstract:
Summary Stroke remains a leading cause of adult disability, and the recovery of motor function after stroke is crucial for the patient to regain independence. However, making accurate predictions of a patient's motor recovery and outcome is difficult when based on clinical assessment alone. Clinical assessment of motor impairment within a few days of stroke can help to predict subsequent recovery, while neurophysiological and neuroimaging biomarkers of corticomotor structure and function can help to predict both motor recovery and motor outcome after stroke. The combination of biomarkers can provide clinically useful information when planning the personalised rehabilitation of a patient. These biomarkers can also be used for patient selection and stratification in trials investigating rehabilitation interventions that are initiated early after stroke. Ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice.read more
Citations
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Journal ArticleDOI
Advances and challenges in stroke rehabilitation.
TL;DR: Several large intervention trials targeting motor recovery report that participants' motor performance improved, but to a similar extent for both the intervention and control groups in most trials.
Journal ArticleDOI
Recovery from stroke: current concepts and future perspectives
TL;DR: It is demonstrated that the combination of neuroimaging and neurostimulation techniques allows a better understanding of how brain plasticity can be modulated to promote the reorganization of neural networks.
Journal ArticleDOI
Effect of Cerebellar Stimulation on Gait and Balance Recovery in Patients With Hemiparetic Stroke: A Randomized Clinical Trial.
Giacomo Koch,Sonia Bonnì,Elias Paolo Casula,Marco Iosa,Stefano Paolucci,Maria Concetta Pellicciari,Alex Martino Cinnera,Viviana Ponzo,Michele Maiella,Silvia Picazio,Fabrizio Sallustio,Carlo Caltagirone +11 more
TL;DR: Patients treated with CRB-iTBS, but not with sham iTBS, showed an improvement of gait and balance functions, as revealed by a pronounced increase in the mean (SE) Berg Balance Scale score.
Journal ArticleDOI
Prediction Tools for Stroke Rehabilitation
TL;DR: Factors known to predict functional outcomes are summarized and any available prediction scores, decision trees, and algorithms that could be used to guide stroke rehabilitation are critiqued.
Journal ArticleDOI
Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke.
Lei Zuo,Lin Zhang,Lin Zhang,Juan Zu,Zan Wang,Bing Han,Biling Chen,Mengjing Cheng,Minzi Ju,Mingyue Li,Guofang Shu,Mengqin Yuan,Wei Jiang,Xufeng Chen,Fuling Yan,Zhijun Zhang,Honghong Yao,Honghong Yao +17 more
TL;DR: Three circRNAs could serve as biomarkers for AIS diagnosis and prediction of stroke outcomes and the elevated levels of circPDS5B and circCDC14A after stroke might be because of increased levels in lymphocytes and granulocytes.
References
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Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
Journal ArticleDOI
Motor recovery after stroke: a systematic review
TL;DR: Although the existing evidence is limited by poor trial designs, some treatments do show promise for improving motor recovery, particularly those that have focused on high-intensity and repetitive task-specific practice.
Journal ArticleDOI
The Fugl-Meyer Assessment of Motor Recovery after Stroke: A Critical Review of Its Measurement Properties
TL;DR: Based on the available evidence, the Fugl-Meyer motor scale is recommended highly as a clinical and research tool for evaluating changes in motor impairment following stroke.
Journal ArticleDOI
Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study
Valery L. Feigin,Rita Krishnamurthi,Priya Parmar,Bo Norrving,George A. Mensah,Derrick A Bennett,Suzanne Barker-Collo,Andrew E. Moran,Ralph L. Sacco,Thomas Truelsen,Stephen M. Davis,Jeyaraj D Pandian,Mohsen Naghavi,Mohammad H. Forouzanfar,Grant Nguyen,Catherine O. Johnson,Theo Vos,Atte Meretoja,Christopher J L Murray,Gregory A. Roth +19 more
TL;DR: Global stroke burden continues to increase globally, and more efficient stroke prevention and management strategies are urgently needed to halt and eventually reverse the stroke pandemic, while universal access to organized stroke services should be a priority.
Journal ArticleDOI
Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
François Chollet,J. Tardy,Jean-François Albucher,Claire Thalamas,Emilie Bérard,Catherine Lamy,Yannick Béjot,Sandrine Deltour,Assia Jaillard,Philippe Niclot,Benoit Guillon,Thierry Moulin,Philippe Marque,Philippe Marque,Philippe Marque,Jérémie Pariente,Catherine Arnaud,Isabelle Loubinoux,Isabelle Loubinoux,Isabelle Loubinoux +19 more
TL;DR: In patients with ischaemic stroke and moderate to severe motor deficit, the early prescription of fluoxetine with physiotherapy enhanced motor recovery after 3 months.